NDLI: Effect of water extract of Trichosanthes dioica fruits in streptozotocin induced diabetic rats.

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Effect of water extract of Trichosanthes dioica fruits in streptozotocin induced diabetic rats.

Content Provider	Europe PMC
Author	Rai, Prashant Kumar Jaiswal, Dolly Rai, Devendra K. Sharma, Bechan Watal, Geeta
Abstract	In rats with streptozotocin induced severe diabetes mellitus, aqueous extract of Trichosanthes dioica fruits at a dose of 1000mg/kg body weight daily once for 28 days reduced the levels of fasting blood glucose, postprandial glucose, asparate amino transferase, alanine amino transferase, alkaline phosphatase, creatinine, urine sugar and urine protein where as total protein and body weight was increased. No toxic effect was observed during LD50. Our study suggests that further detailed toxicity studies and mechanism of action of T. dioica would be useful for undertaking human trials.
Related Links	https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC3453146&blobtype=pdf
ISSN	09701915
Volume Number	23
DOI	10.1007/s12291-008-0085-4
PubMed Central reference number	PMC3453146
Issue Number	4
PubMed reference number	23105793
Journal	Indian Journal of Clinical Biochemistry [Indian J Clin Biochem]
e-ISSN	09740422
Language	English
Publisher	Springer-Verlag
Publisher Date	2008-10-01
Publisher Place	India
Access Restriction	Open
Rights License	© Association of Clinical Biochemists of India 2008
Subject Keyword	Antidiabetic effect Hepatoprotective Trichosanthes dioica
Content Type	Text
Resource Type	Article
Subject	Clinical Biochemistry

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