Highly sensitive magnetite nano clusters for MR cell imaging.

Content Provider	Europe PMC
Author	Li, Mingli Gu, Hongchen Zhang, Chunfu
Copyright Year	2012
Abstract	High sensitivity and suitable sizes are essential for magnetic iron oxide contrast agents for cell imaging. In this study, we have fabricated highly MR sensitive magnetite nanoclusters (MNCs) with tunable sizes. These clusters demonstrate high MR sensitivity. Especially, water suspensions of the MNCs with average size of 63 nm have transverse relaxivity as high as 630 s-1mM-1, which is among the most sensitive iron oxide contrast agents ever reported. Importantly, such MNCs have no adverse effects on cells (RAW 264.7). When used for cell imaging, they demonstrate much higher efficiency and sensitivity than those of SHU555A (Resovist), a commercially available contrast agent, both in vitro and in vivo, with detection limits of 3,000 and 10,000 labeled cells, respectively. The studied MNCs are sensitive for cell imaging and promising for MR cell tracking in clinics.
ISSN	19317573
Journal	Nanoscale Research Letters
Volume Number	7
PubMed Central reference number	PMC3366891
Issue Number	1
PubMed reference number	22462693
e-ISSN	1556276X
DOI	10.1186/1556-276x-7-204
Language	English
Publisher	Springer
Publisher Date	2012-03-31
Access Restriction	Open
Rights License	This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Copyright ©2012 Li et al; licensee Springer.
Subject Keyword	Magnetic resonance imaging magnetic nano cluster cell imaging polyol method
Content Type	Text
Resource Type	Article
Subject	Nanoscience and Nanotechnology Condensed Matter Physics Materials Science