Screening Togolese medicinal plants for few pharmacological properties.

Content Provider	Europe PMC
Author	Karou, Simplice D. Tchacondo, Tchadjobo Tchibozo, Micheline Agassounon Djikpo Anani, Kokou Ouattara, Lassina Simpore, Jacques de Souza, Comlan
Copyright Year	2012
Abstract	Background:Terminalia macroptera Guill. et Perr. (Combretaceae), Sida alba L. (Malvaceae), Prosopis africana Guill et Perr. Taub. (Mimosaceae), Bridelia ferruginea Benth. (Euphorbiaceae), and Vetiveria nigritana Stapf. (Asteraceae) are traditionally used in Togolese folk medicine to treat several diseases including microbial infections.Objective:This study aimed to investigate the antimicrobial, antioxidant, and hemolytic properties of the crude extracts of the above-mentioned plants.Materials and Methods:The antimicrobial and the antioxidant activities were assayed using the NCCLS microdilution method and the DPPH free radical scavenging, respectively. Human A+ red blood cells were used to perform the hemolytic assay. Phenolics were further quantified in the extracts using spectrophotometric methods.Results:Minimal inhibitory concentrations in the range of 230-1800 μg/ml were recorded in the NCCLS broth microdilution for both bacterial and fungal strains with methanol extracts. The DPPH radical scavenging assay yielded interesting antioxidant activities of the extracts of P. africana and T. macroptera (IC50 values of 0.003 ± 0.00 μg/ml and 0.05 ± 0.03 μg/ml, respectively). These activities were positively correlated with the total phenolic contents and negatively correlated with the proanthocyanidin content of the extracts. The hemolytic assay revealed that great hemolysis occurred with the methanol extracts of T. macroptera, S. longepedunculata, and B. ferruginea.Conclusion:These results support in part the use of the selected plants in the treatment of microbial infections. In addition, the plant showed an interesting antioxidant activity that could be useful in the management of oxidative stress.
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ISSN	09764836
Journal	Pharmacognosy Research [Pharmacognosy Res]
Volume Number	4
DOI	10.4103/0974-8490.94737
PubMed Central reference number	PMC3326758
Issue Number	2
PubMed reference number	22518084
e-ISSN	09748490
Language	English
Publisher	Medknow Publications & Media Pvt Ltd
Publisher Date	2012-04-01
Publisher Place	India
Access Restriction	Open
Rights License	This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Copyright: © Pharmacognosy Research
Subject Keyword	Antimicrobial antioxidant hemolytic phenolics
Content Type	Text
Resource Type	Article
Subject	Drug Discovery Pharmacology