NDLI: NADPH oxidase mediated oxidative stress in hepatic fibrogenesis.

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NADPH oxidase mediated oxidative stress in hepatic fibrogenesis.

Content Provider	Europe PMC
Author	Paik, Yong-Han Brenner, David A.
Copyright Year	2011
Abstract	NADPH oxidase (NOX) is a multicomponent enzyme complex that generates reactive oxygen species (ROS) in response to a wide range of stimuli. ROS is involved as key secondary messengers in numerous signaling pathways, and NADPH oxidases complex has been increasingly recognized as key elements of intracellular signaling of hepatic fibrogenesis. In the liver, NADPH oxidase is functionally expressed both in the phagocytic form and in the non-phagocytic form. The non-phagocytic NADPH oxidase complex is structurally and functionally similar to the phagocytic NADPH, resulting in reduction of molecular oxygen to generate superoxide. There are six homologous NOX proteins in the non-phagocytic forms of NADPH oxidase. An emerging concept is that both phagocytic and nonphagocytic NADPH oxidase components in hepatic stellate cells (HSCs) mediate hepatic fibrosis, suggesting its potential role as a pharmacological target for anti-fibrotic therapy. The molecular components and signaling pathways of various NADPH oxidase homologues that are critical for the fibrotic activity in HSCs need to be more clearly identified.
Related Links	https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC3304665&blobtype=pdf
ISSN	1738222X
Volume Number	17
DOI	10.3350/kjhep.2011.17.4.251
PubMed Central reference number	PMC3304665
Issue Number	4
PubMed reference number	22310788
Journal	The Korean Journal of Hepatology [Korean J Hepatol]
e-ISSN	20938047
Language	English
Publisher	The Korean Association for the Study of the Liver
Publisher Date	2011-12-01
Access Restriction	Open
Rights License	This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. Copyright © 2011 by The Korean Association for the Study of the Liver
Subject Keyword	NADPH oxidase Reactive oxygen species Oxidative stress Hepatic fibrosis Hepatic stellate cell
Content Type	Text
Resource Type	Article
Subject	Medicine

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