Inflammatory bowel disease associated arthropathy.

Content Provider	Europe PMC
Author	Arvikar, Sheila L. Fisher, Mark C.
Abstract	Arthritis is the most common extraintestinal manifestation of inflammatory bowel disease (IBD) and can have a significant impact on morbidity and quality of life. IBD-associated arthropathy is considered a subtype of seronegative spondyloarthropathy, with axial, peripheral, or a combination of both joint manifestations. Peripheral arthritis is generally non-erosive and the oligoarticular variant particularly may correlate with intestinal disease activity. Axial arthritis may include inflammatory back pain, sacroiliitis, or ankylosing spondylitis, and is less likely to correlate with gastrointestinal symptoms. While there have been advances in identifying predisposing genetic factors and in elucidating pathophysiology of inflammatory bowel disease, the mechanisms surrounding the development of arthritis in IBD remain unclear. Treatment of inflammatory bowel disease is not always sufficient for control of arthritis. While treatment with biologic agents is promising, there remains a great need for larger, randomized studies to address optimal therapy of IBD associated arthropathy.
Related Links	https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC3261248&blobtype=pdf
ISSN	1935973X
Volume Number	4
DOI	10.1007/s12178-011-9085-8
PubMed Central reference number	PMC3261248
Issue Number	3
PubMed reference number	21710141
Journal	Current Reviews in Musculoskeletal Medicine [Curr Rev Musculoskelet Med]
e-ISSN	19359748
Language	English
Publisher	Current Science Inc.
Publisher Date	2011-09-01
Publisher Place	New York
Access Restriction	Open
Rights License	© Springer Science+Business Media, LLC 2011
Subject Keyword	Inflammatory bowel disease IBD Arthritis Ulcerative colitis Crohn’s disease Extraintestinal manifestations DMARDS Biologics
Content Type	Text
Resource Type	Article
Subject	Orthopedics and Sports Medicine