NDLI: Targeted gold nanoparticles enable molecular CT imaging of cancer: an in vivo study.

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Targeted gold nanoparticles enable molecular CT imaging of cancer: an in vivo study.

Content Provider	Europe PMC
Author	Reuveni, Tobi Motiei, Menachem Romman, Zimam Popovtzer, Aron Popovtzer, Rachela
Copyright Year	2011
Abstract	In recent years, advances in molecular biology and cancer research have led to the identification of sensitive and specific biomarkers that associate with various types of cancer. However, in vivo cancer detection methods with computed tomography, based on tracing and detection of these molecular cancer markers, are unavailable today. This paper demonstrates in vivo the feasibility of cancer diagnosis based on molecular markers rather than on anatomical structures, using clinical computed tomography. Anti-epidermal growth factor receptor conjugated gold nanoparticles (30 nm) were intravenously injected into nude mice implanted with human squamous cell carcinoma head and neck cancer. The results clearly demonstrate that a small tumor, which is currently undetectable through anatomical computed tomography, is enhanced and becomes clearly visible by the molecularly-targeted gold nanoparticles. It is further shown that active tumor targeting is more efficient and specific than passive targeting. This noninvasive and nonionizing molecular cancer imaging tool can facilitate early cancer detection and can provide researchers with a new technique to investigate in vivo the expression and activity of cancer-related biomarkers and molecular processes.
ISSN	11769114
Journal	International Journal of Nanomedicine
Volume Number	6
PubMed Central reference number	PMC3224712
PubMed reference number	22131831
e-ISSN	11782013
DOI	10.2147/ijn.s25446
Language	English
Publisher	Dove Medical Press
Publisher Date	2011-11-11
Access Restriction	Open
Rights License	This is an Open Access article which permits unrestricted noncommercial use, provided the original work is properly cited. © 2011 Reuveni et al, publisher and licensee Dove Medical Press Ltd.
Subject Keyword	functional computed tomography molecular imaging gold nanoparticles biologically targeted in vivo imaging contrast agents
Content Type	Text
Resource Type	Article
Subject	Nanoscience and Nanotechnology Organic Chemistry Drug Discovery Medicine Biomaterials Biophysics Bioengineering Pharmaceutical Science

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