NDLI: Effect of initial ziprasidone dose on treatment outcome of korean patients with acute manic or mixed episodes.

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Effect of initial ziprasidone dose on treatment outcome of korean patients with acute manic or mixed episodes.

Content Provider	Europe PMC
Author	Woo, Young Sup Bahk, Won-Myong Jo, Soo Hyun Yoon, Bo-Hyun Lee, Jung Goo Kim, Won Jeong, Jong-Hyun Seo, Jeong Seok Min, Kyung Joon Jon, Duk-In
Copyright Year	2011
Abstract	ObjectiveWe investigated the efficacy and tolerability of ziprasidone combined with divalproex to determine the relationship between the initial dose of ziprasidone and the treatment effect among Korean patients with acute bipolar manic or mixed disorders.MethodsThis study was a 6-week, open-label, prospective investigation of Korean patients with an acute manic or mixed episode of bipolar disorder. Sixty-five patients were recruited. The patients were categorized based on the initial dose of ziprasidone as follows: low (20-79 mg/day) and standard (80 mg/day). Ziprasidone was given in combination with divalproex in flexible doses, according to the clinical response and tolerability.ResultsThe response and remission rates were significantly higher in the standard-dose group than the low-dose group. The combination of ziprasidone and divalproex was well-tolerated and adverse events were mostly mild with no statistically significant increase in body weight.ConclusionThe results of this study showed that a standard starting dose of ziprasidone in combination with divalproex for bipolar disorder is more effective than a low starting dose.
ISSN	17383684
Journal	Psychiatry Investigation
Volume Number	8
PubMed Central reference number	PMC3182385
Issue Number	3
PubMed reference number	21994507
e-ISSN	19763026
DOI	10.4306/pi.2011.8.3.207
Language	English
Publisher	Korean Neuropsychiatric Association
Publisher Date	2011-08-02
Access Restriction	Open
Rights License	This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. Copyright © 2011 Korean Neuropsychiatric Association
Subject Keyword	Bipolar disorder Divalproex Initial dose Manic episode Ziprasidone
Content Type	Text
Resource Type	Article
Subject	Biological Psychiatry Psychiatry and Mental Health

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