Loading...
Please wait, while we are loading the content...
Similar Documents
Nano-zinc oxide damages spatial cognition capability via over-enhanced long-term potentiation in hippocampus of Wistar rats.
| Content Provider | Europe PMC |
|---|---|
| Author | Han, Dadong Tian, Yutao Zhang, Tao Ren, Guogang Yang, Zhuo |
| Copyright Year | 2011 |
| Abstract | This study focused on the effects of zinc oxide nanoparticles (nano-ZnO) on spatial learning and memory and synaptic plasticity in the hippocampus of young rats, and tried to interpret the underlying mechanism. Rats were randomly divided into four groups. Nano-ZnO and phosphate-buffered saline were administered in 4-week-old rats for 8 weeks. Subsequently, performance in Morris water maze (MWM) was determined, and then long-term potentiation (LTP) and depotentiation were measured in the perforant pathway to dentate gyrus (DG) in anesthetized rats. The data showed that, (1) in MWM, the escape latency was prolonged in the nano-ZnO group and, (2) LTP was significantly enhanced in the nano-ZnO group, while depotentiation was barely influenced in the DG region of the nano-ZnO group. This bidirectional effect on long-term synaptic plasticity broke the balance between stability and flexibility of cognition. The spatial learning and memory ability was attenuated by the alteration of synaptic plasticity in nano-ZnO-treated rats. |
| ISSN | 11769114 |
| Journal | International Journal of Nanomedicine |
| Volume Number | 6 |
| PubMed Central reference number | PMC3141872 |
| PubMed reference number | 21796247 |
| e-ISSN | 11782013 |
| DOI | 10.2147/ijn.s18507 |
| Language | English |
| Publisher | Dove Medical Press |
| Publisher Date | 2011-07-11 |
| Access Restriction | Open |
| Rights License | This is an Open Access article which permits unrestricted noncommercial use, provided the original work is properly cited. © 2011 Han et al, publisher and licensee Dove Medical Press Ltd. |
| Subject Keyword | zinc oxide nanoparticles synaptic plasticity long-term potentiation depotentiation spatial learning memory |
| Content Type | Text |
| Resource Type | Article |
| Subject | Nanoscience and Nanotechnology Organic Chemistry Drug Discovery Medicine Biomaterials Biophysics Bioengineering Pharmaceutical Science |
