NDLI: Brine shrimp lethality and acute oral toxicity studies on Swietenia mahagoni (Linn.) Jacq. seed methanolic extract.

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Brine shrimp lethality and acute oral toxicity studies on Swietenia mahagoni (Linn.) Jacq. seed methanolic extract.

Content Provider	Europe PMC
Author	Sahgal, Geethaa Ramanathan, Surash Sasidharan, Sreenivasan Mordi, Mohd. Nizam Ismail, Sabariah Mansor, Sharif Mahsufi
Copyright Year	2010
Abstract	Background:The seeds of Swietenia mahagoni have been applied in folk medicine for the treatment of hypertension, diabetes, malaria, amoebiasis, cough, chest pain, and intestinal parasitism. Here we are the first to report on the toxicity of the Swietenia mahagoni crude methanolic (SMCM) seed extract.Methods:SMCM seed extract has been studied for its brine shrimp lethality and acute oral toxicity, in mice.Results:The brine shrimp lethality bioassay shows a moderate cytotoxicity at high concentration. The LC50 for the extract is 0.68 mg/ml at 24 hours of exposure. The LD50 of the SMCM seed extract for acute oral toxicity in mice is greater than 5000 mg/kg.Conclusion:This study demonstrates that Swietenia mahagoni crude methanolic seed extract may contain bioactive compounds of potential therapeutic significance which are relatively safe from toxic effects, and can compromise the medicinal use of this plant in folk medicine.
Related Links	https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC3141130&blobtype=pdf
ISSN	09764836
Journal	Pharmacognosy Research [Pharmacognosy Res]
Volume Number	2
DOI	10.4103/0974-8490.69107
PubMed Central reference number	PMC3141130
Issue Number	4
PubMed reference number	21808570
e-ISSN	09748490
Language	English
Publisher	Medknow Publications Pvt Ltd
Publisher Date	2010-07-01
Publisher Place	India
Access Restriction	Open
Rights License	This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 3.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Copyright: © Pharmacognosy Research
Subject Keyword	Acute oral toxicity brine Shrimp Swietenia mahagoni seeds
Content Type	Text
Resource Type	Article
Subject	Drug Discovery Pharmacology

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