NDLI: Thyroxine and free thyroxine levels in workers occupationally exposed to inorganic lead.

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Thyroxine and free thyroxine levels in workers occupationally exposed to inorganic lead.

Content Provider	Europe PMC
Author	Bledsoe, Michael L. Pinkerton, Lynne E. Silver, Sharon Deddens, James A. Biagini, Raymond E.
Copyright Year	2011
Abstract	Background:The effects of lead exposure on thyroid function are unclear.Methods:Serum thyroxine (T4) was evaluated among 137 lead-exposed workers and 83 non-exposed workers. Free thyroxine (FT4) was evaluated among a subset of these workers. Exposure metrics included blood lead level (BLL), which reflects recent exposure, zinc protoporphyrin (ZPP), a marker of intermediate-duration lead exposure, exposure duration, and estimated cumulative exposure. Multiple linear regression results were adjusted for age, race, and current smoking status.Results:Mean BLLs were 38.9 μg/dL in lead exposed workers and 2.1 μg/dL in non-exposed workers. The adjusted mean T4 and FT4 concentrations among exposed and non-exposed workers were similar. While T4 was not significantly related to any of the exposure metrics, FT4 was inversely related to the logged values of both exposure duration and cumulative exposure, but not to ZPP or BLL.Conclusions:The findings suggest that FT4 levels may be related to long-term lead exposure.
Related Links	https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC3140278&blobtype=pdf
Journal	Environmental Health Insights [Environ Health Insights]
Volume Number	5
PubMed Central reference number	PMC3140278
PubMed reference number	21792313
e-ISSN	11786302
DOI	10.4137/ehi.s7193
Language	English
Publisher	Libertas Academica
Publisher Date	2011-06-14
Access Restriction	Open
Rights License	This is an open access article. Unrestricted non-commercial use is permitted provided the original work is properly cited. © the author(s), publisher and licensee Libertas Academica Ltd.
Subject Keyword	thyroxine free thyroxine lead occupational exposure
Content Type	Text
Resource Type	Article
Subject	Management, Monitoring, Policy and Law Health, Toxicology and Mutagenesis Pollution Public Health, Environmental and Occupational Health

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