The Use of Commercially Available Alpha-Amylase Compounds to Inhibit and Remove Staphylococcus aureus Biofilms.

Content Provider	Europe PMC
Author	Craigen, Bradford Dashiff, Aliza Kadouri, Daniel E
Copyright Year	2011
Abstract	Staphylococcus aureus, a versatile human pathogen, is commonly associated with medical device infections. Its capacity to establish and maintain these infections is thought to be related to its ability to form adherent biofilms. In this study, commercially available α-amylase compounds from various biological sources were evaluated for their ability to reduce and prevent biofilm formation of several S. aureus isolates. Our data demonstrates that α-amylase compounds can rapidly detach biofilms of S. aureus, as well as inhibit biofilm formation. Our data also demonstrates that α-amylase compounds have an ability to reduce and disassociate S. aureus cell-aggregates grown in liquid suspension. These findings suggest that commercially available α-amylase compounds could be used in the future to control S. aureus biofilm-related infections.
Related Links	https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC3134978&blobtype=pdf
Journal	The Open Microbiology Journal [Open Microbiol J]
Volume Number	5
DOI	10.2174/1874285801105010021
PubMed Central reference number	PMC3134978
PubMed reference number	21760865
e-ISSN	18742858
Language	English
Publisher	Bentham Open
Publisher Date	2011-06-01
Access Restriction	Open
Rights License	This is an open access article licensed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, provided the work is properly cited. © Craigen et al.; Licensee Bentham Open.
Subject Keyword	Staphylococcus aureus α-amylases Biofilm control Biofilm-dispersing enzymes.
Content Type	Text
Resource Type	Article
Subject	Immunology and Microbiology