Variant Burkitt-type translocation (8;22)(q24;q11) in plasma cell myeloma.

Content Provider	Europe PMC
Author	Kim, Hanah Moon, Hee-Won Hur, Mina Yun, Yeo-Min Park, Chul-Min Lee, Mark Hong
Copyright Year	2011
Abstract	Variant Burkitt-type translocation, t(8;22)(q24;q11), is very rare in plasma cell myeloma. We report a 51-year-old male patient with plasma cell myeloma, who showed t(8;22) (q24;q11). He suffered from pelvic pain for two months, and showed IgG, lambda type of monoclonal gammopathy (5.14 g/dL; 49.9% of protein). His bone marrow examination showed increased plasma cells (66.9% of all nucleated cells). Plasma cells (74.9% of all nucleated cells) and monoclonal spike (3.38 g/dL; 42.2%) persisted after three cycles of thalidomide and dexamethasone. Cytogenetic analysis showed complex chromosomal abnormalities: 44,XY,-1,t(2;5)(q33;q13),add(8)(q24.1),t(8;22)(q24.1;q11.2),add(10) (p15), der(11)t(1;11)(q21;p11.2),del(12)(p11.2p13),-13,-14,add(14)(q32),der(15)t(1;15)(p2 2;p11.2),-16,add(17)(q11.2),+21,+1-3mar[cp6]/46,XY[19]. To the best of our knowledge, this is the first report on plasma cell myeloma with a variant Burkitt-type t(8;22)(q24;q11) in the Korean patient. A review of 11 such cases in the literature, including the present case, implicated that plasma cell myeloma with t(8;22)(q24;q11) might be related to advanced stage and poor prognosis.
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ISSN	17387949
Journal	The Korean Journal of Hematology [Korean J Hematol]
Volume Number	46
DOI	10.5045/kjh.2011.46.2.135
PubMed Central reference number	PMC3128895
Issue Number	2
PubMed reference number	21747887
e-ISSN	20929129
Language	English
Publisher	Korean Society of Hematology; Korean Society of Blood and Marrow Transplantation; Korean Society of Pediatric Hematology-Oncology; Korean Society on Thrombosis and Hemostasis
Publisher Date	2011-06-21
Access Restriction	Open
Rights License	This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. © 2011 Korean Society of Hematology
Subject Keyword	Plasma cell myeloma q11) t(8 22)(q24 Variant Burkitt
Content Type	Text
Resource Type	Article
Subject	Hematology