NDLI: Ultrastructural changes in Cryptosporidium parvum oocysts by gamma irradiation.

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Ultrastructural changes in Cryptosporidium parvum oocysts by gamma irradiation.

Content Provider	Europe PMC
Author	Joung, Migyo Yun, Sejeong Joung, Mijoung Park, Woo-Yoon Yu, Jae-Ran
Copyright Year	2011
Abstract	Cryptosporidium parvum is known as one of the most highly resistant parasites to gamma irradiation. To morphologically have an insight on the radioresistance of this parasite, ultrastructural changes in C. parvum sporozoites were observed after gamma irradiation using various doses (1, 5, 10, and 25 kGy) following a range of post-irradiation incubation times (10 kGy for 6, 12, 24, 48, 72, and 96 hr). The ultrastructures of C. parvum oocysts changed remarkably after a 10-kGy irradiation. Nuclear membrane changes and degranulation of dense granules were observed with high doses over 10 kGy, and morphological changes in micronemes and rhoptries were observed with very high doses over 25 kGy. Oocyst walls were not affected by irradiation, whereas the internal structures of sporozoites degenerated completely 96 hr post-irradiation using a dose of 10 kGy. From this study, morphological evidence of radioresistance of C. parvum has been supplemented.
ISSN	00234001
Journal	The Korean Journal of Parasitology
Volume Number	49
PubMed Central reference number	PMC3063922
Issue Number	1
PubMed reference number	21461265
e-ISSN	17380006
DOI	10.3347/kjp.2011.49.1.25
Language	English
Publisher	The Korean Society for Parasitology
Publisher Date	2011-03-18
Access Restriction	Open
Rights License	This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. © 2011, Korean Society for Parasitology
Subject Keyword	Cryptosporidium parvum ultrastructure gamma irradiation
Content Type	Text
Resource Type	Article
Subject	Infectious Diseases Parasitology

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