Image-guided optical spectroscopy in diagnosis of osteoarthritis: a clinical study.

Content Provider	Europe PMC
Author	Yuan, Zhen Zhang, Qizhi Sobel, Eric S. Jiang, Huabei
Copyright Year	2010
Abstract	This goal of this study was to clinically evaluate the potential of a novel hybrid imaging techniques, called x-ray guided multispectral diffuse optical tomography, for identifying physiological parameters of joint tissues that can be used to distinguish between osteoarthritic and healthy joints in the hand. Between 2006 and 2009, the distal interphalangeal (DIP) finger joints from 40 subjects including 22 osteoarthritis patients and 18 healthy controls were examined clinically and scanned by the hybrid imaging platform that integrated a C-arm based x-ray tomosynthetic system with a mutlispectral diffuse optical imaging system. Based on the reconstructed results from the 40 subjects, it was observed that oxygen saturation and water content were two statistically most significant physiological discriminators for differentiation of the healthy joints from the osteoarthritic ones.
Journal	Biomedical Optics Express
Volume Number	1
PubMed Central reference number	PMC3005153
Issue Number	1
PubMed reference number	21258447
e-ISSN	21567085
DOI	10.1364/BOE.1.000074
Language	English
Publisher	Optical Society of America
Publisher Date	2010-07-14
Access Restriction	Open
Rights License	This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 Unported License, which permits download and redistribution, provided that the original work is properly cited. This license restricts the article from being modified or used commercially. ©2010 Optical Society of America
Subject Keyword	(170.4580) Optical diagnostics for medicine (170.0110) Imaging systems
Content Type	Text
Resource Type	Article
Subject	Biotechnology Atomic and Molecular Physics, and Optics