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Polybrominated diphenyl ether (PBDE) flame retardants and thyroid hormone during pregnancy.
| Content Provider | Europe PMC |
|---|---|
| Author | Chevrier, Jonathan Harley, Kim G. Bradman, Asa Gharbi, Myriam Sjödin, Andreas Eskenazi, Brenda |
| Copyright Year | 2010 |
| Abstract | BackgroundHuman exposure to polybrominated diphenyl ether (PBDE) flame retardants has increased exponentially over the last three decades. Animal and human studies suggest that PBDEs may disrupt thyroid function. Although thyroid hormone (TH) of maternal origin plays an essential role in normal fetal brain development, there is a paucity of human data regarding associations between exposure to PBDEs and maternal TH levels during pregnancy.ObjectivesOur goal was to determine whether PBDE serum concentrations are associated with TH levels in pregnant women.MethodsWe measured the concentration of 10 PBDE congeners, free thyroxine (T4), total T4, and thyroid-stimulating hormone (TSH) in 270 pregnant women around the 27th week of gestation.ResultsSerum concentrations of individual PBDE congeners with detection frequencies > 50% (BDEs 28, 47, 99, 100, and 153) and their sum (∑PBDEs) were inversely associated with TSH levels. Decreases in TSH ranged between 10.9% [95% confidence interval (CI), −20.6 to 0.0] and 18.7% (95% CI, −29.2 to −4.5) for every 10-fold increase in the concentration of individual congeners. Odds of subclinical hyperthyroidism (low TSH but normal T4) were also significantly elevated in participants in the highest quartile of ∑PBDEs and BDEs 100 and 153 relative to those in the first quartile. Associations between PBDEs and free and total T4 were not statistically significant. Results were not substantially altered after the removal of outliers and were independent of the method used to adjust for blood lipid levels and to express ∑PBDEs.ConclusionsResults suggest that exposure to PBDEs is associated with lower TSH during pregnancy. Findings may have implications for maternal health and fetal development. |
| ISSN | 00916765 |
| Journal | Environmental Health Perspectives |
| Volume Number | 118 |
| PubMed Central reference number | PMC2957927 |
| Issue Number | 10 |
| PubMed reference number | 20562054 |
| e-ISSN | 15529924 |
| DOI | 10.1289/ehp.1001905 |
| Language | English |
| Publisher | National Institute of Environmental Health Sciences |
| Publisher Date | 2010-06-11 |
| Access Restriction | Open |
| Rights License | Publication of EHP lies in the public domain and is therefore without copyright. All text from EHP may be reprinted freely. Use of materials published in EHP should be acknowledged (for example, ?Reproduced with permission from Environmental Health Perspectives?); pertinent reference information should be provided for the article from which the material was reproduced. Articles from EHP, especially the News section, may contain photographs or illustrations copyrighted by other commercial organizations or individuals that may not be used without obtaining prior approval from the holder of the copyright. |
| Subject Keyword | endocrine disruption flame retardants persistent organic pollutants polybrominated diphenyl ethers (PBDEs) pregnancy thyroid hormone |
| Content Type | Text |
| Resource Type | Article |
| Subject | Health, Toxicology and Mutagenesis Public Health, Environmental and Occupational Health |
