NDLI: Progress in antiretroviral drug delivery using nanotechnology.

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Progress in antiretroviral drug delivery using nanotechnology.

Content Provider	Europe PMC
Author	Mallipeddi, Rama Rohan, Lisa Cencia
Abstract	There are currently a number of antiretroviral drugs that have been approved by the Food and Drug Administration for use in the treatment of human immunodeficiency virus (HIV). More recently, antiretrovirals are being evaluated in the clinic for prevention of HIV infection. Due to the challenging nature of treatment and prevention of this disease, the use of nanocarriers to achieve more efficient delivery of antiretroviral drugs has been studied. Various forms of nanocarriers, such as nanoparticles (polymeric, inorganic, and solid lipid), liposomes, polymeric micelles, dendrimers, cyclodextrins, and cell-based nanoformulations have been studied for delivery of drugs intended for HIV prevention or therapy. The aim of this review is to provide a summary of the application of nanocarrier systems to the delivery of anti-HIV drugs, specifically antiretrovirals. For anti-HIV drugs to be effective, adequate distribution to specific sites in the body must be achieved, and effective drug concentrations must be maintained at those sites for the required period of time. Nanocarriers provide a means to overcome cellular and anatomical barriers to drug delivery. Their application in the area of HIV prevention and therapy may lead to the development of more effective drug products for combating this pandemic disease.
ISSN	11769114
Journal	International Journal of Nanomedicine
Volume Number	5
PubMed Central reference number	PMC2950411
PubMed reference number	20957115
e-ISSN	11782013
DOI	10.2217/nnm.10.25
Language	English
Publisher	Dove Medical Press
Publisher Date	2010-08-09
Access Restriction	Open
Rights License	This is an Open Access article which permits unrestricted noncommercial use, provided the original work is properly cited. © 2010 Mallipeddi and Rohan, publisher and licensee Dove Medical Press Ltd.
Subject Keyword	drug delivery HIV antiretrovirals nanoparticles liposomes dendrimers
Content Type	Text
Resource Type	Article
Subject	Nanoscience and Nanotechnology Organic Chemistry Drug Discovery Medicine Biomaterials Biophysics Bioengineering Pharmaceutical Science

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