Neuroprotective effects of consuming bovine colostrum after focal brain ischemia/reperfusion injury in rat model.

Content Provider	Europe PMC
Author	Choi, Han Sung Ko, Young Gwan Lee, Jong Seok Kwon, Oh Young Kim, Sun-Kyu Cheong, Chul Jang, Ki-Hyo Kang, Soon Ah
Copyright Year	2010
Abstract	To investigate the neuroprotective effects of bovine colostrums (BC), we evaluate the ability of consuming BC after focal brain ischemia/reperfusion injury rat model to reduce serum cytokine levels and infarct volume, and improve neurological outcome. Sprague-Dawley rats were randomly divided into 4 groups; one sham operation and three experimental groups. In the experimental groups, MCA occlusion (2 h) and subsequent reperfusion (O/R) were induced with regional cerebral blood flow monitoring. One hour after MCAO/R and once daily during the experiment, the experimental group received BC while the other groups received 0.9% saline or low fat milk (LFM) orally. Seven days later, serum pro-inflammatory cytokine (IL-1β, IL-6, and TNF-α) and anti-inflammatory cytokine (IL-10) levels were assessed. Also, the infarct volume was assessed by using a computerized image analysis system. Behavioral function was also assessed using a modified neurologic severity score and corner turn test during the experiment. Rats receiving BC after focal brain I/R showed a significant reduction (-26%/-22%) in infarct volume compared to LFM/saline rats, respectively (P < 0.05). Serum IL-1β, IL-6, and TNF-α levels were decreased significantly in rats receiving BC compared to LFM/saline rats (P < 0.05). In behavioral tests, daily BC intake showed consistent and significant improvement of neurological deficits for 7 days after MCAO/R. BC ingestion after focal brain ischemia/reperfusion injury may prevent brain injury by reducing serum pro-inflammatory cytokine levels and brain infarct volume in a rat model.
ISSN	19761457
Journal	Nutrition Research and Practice
Volume Number	4
PubMed Central reference number	PMC2895699
Issue Number	3
PubMed reference number	20607064
e-ISSN	20056168
DOI	10.4162/nrp.2010.4.3.196
Language	English
Publisher	The Korean Nutrition Society and the Korean Society of Community Nutrition
Publisher Date	2010-06-29
Access Restriction	Open
Rights License	This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. ©2010 The Korean Nutrition Society and the Korean Society of Community Nutrition
Subject Keyword	Focal brain ischemia/reperfusion bovine colostrum cytokines neuroprotection
Content Type	Text
Resource Type	Article
Subject	Nutrition and Dietetics Food Science