Propofol has delayed myocardial protective effects after a regional ischemia/reperfusion injury in an in vivo rat heart model.

Content Provider	Europe PMC
Author	Shin, Il Woo Jang, In Seok Lee, Seung-Hwa Baik, Ji-Seok Park, Kyeong-Eon Sohn, Ju-Tae Lee, Heon Keun Chung, Young Kyun
Copyright Year	2010
Abstract	BackgroundIt is well known that propofol protects myocardium against myocardial ischemia/reperfusion injury in the rat heart model. The aim of this study was to investigate whether propofol provides a protective effect against a regional myocardial ischemia/reperfusion injury in an in vivo rat heart model after 48 h of reperfusion.MethodsRats were subjected to 25 min of left coronary artery occlusion followed by 48 h of reperfusion. The sham group received profopol without ischemic injury. The control group received normal saline with ischemia/reperfusion injury. The propofol group received profopol with ischemia/reperfusion injury. The intralipid group received intralipid with ischemia/reperfusion injury. A microcatheter was advanced into the left ventricle and the hemodynamic function was evaluated. The infarct size was determined by triphenyltetrazolium staining. The serum level of cardiac troponin-I (cTn-I) was determined by ELISA (enzyme-linked immunosorbent assay).ResultsPropofol demonstrated protective effects on hemodynamic function and infarct size reduction. In the propofol group, the +dP/dtmax (P = 0.002) was significantly improved compared to the control group. The infarct size was 49.8% of the area at risk in the control group, and was reduced markedly by administration of propofol to 32.6% in the propofol group (P = 0.014). The ischemia/reperfusion-induced serum level of cTn-I was reduced by propofol infusion during the peri-ischemic period (P = 0.0001).ConclusionsPropofol, which infused at clinically relevant concentration during the peri-ischemic period, has delayed myocardial protective effect after regional myocardial ischemia/reperfusion injury in an in vivo rat heart model after 48 h of reperfusion.
ISSN	20056419
Journal	Korean Journal of Anesthesiology
Volume Number	58
PubMed Central reference number	PMC2876860
Issue Number	4
PubMed reference number	20508796
e-ISSN	20057563
DOI	10.4097/kjae.2010.58.4.378
Language	English
Publisher	The Korean Society of Anesthesiologists
Publisher Date	2010-04-28
Access Restriction	Open
Rights License	This is an open-access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. Copyright © The Korean Society of Anesthesiologists, 2010
Subject Keyword	Ischemia/reperfusion injury Myocardium Propofol
Content Type	Text
Resource Type	Article
Subject	Anesthesiology and Pain Medicine