Malondialdehyde-deoxyguanosine adducts among workers of a Thai industrial estate and nearby residents.

Content Provider	Europe PMC
Author	Peluso, Marco Srivatanakul, Petcharin Munnia, Armelle Jedpiyawongse, Adisorn Ceppi, Marcello Sangrajrang, Suleeporn Piro, Sara Boffetta, Paolo
Copyright Year	2010
Abstract	BackgroundHumans living near industrial point emissions can experience high levels of exposures to air pollutants. Map Ta Phut Industrial Estate in Thailand is the location of the largest steel, oil refinery, and petrochemical factory complexes in Southeast Asia. Air pollution is an important source of oxidative stress and reactive oxygen species, which interact with DNA and lipids, leading to oxidative damage and lipid peroxidation, respectively.ObjectiveWe measured the levels of malondialdehyde–deoxyguanosine (dG) adducts, a biomarker of oxidative stress and lipid peroxidation, in petrochemical workers, nearby residents, and subjects living in a control district without proximity to industrial sources.DesignWe conducted a cross-sectional study to compare the prevalence of malondialdehyde-dG adducts in groups of subjects experiencing various degrees of air pollution.ResultsThe multivariate regression analysis shows that the adduct levels were associated with occupational and environmental exposures to air pollution. The highest adduct level was observed in the steel factory workers. In addition, the formation of DNA damage tended to be associated with tobacco smoking, but without reaching statistical significance. A nonsignificant increase in DNA adducts was observed after 4–6 years of employment among the petrochemical complexes.ConclusionsAir pollution emitted from the Map Ta Phut Industrial Estate complexes was associated with increased adduct levels in petrochemical workers and nearby residents. Considering the mutagenic potential of DNA lesions in the carcinogenic process, we recommend measures aimed at reducing the levels of air pollution.
ISSN	00916765
Journal	Environmental Health Perspectives
Volume Number	118
PubMed Central reference number	PMC2831967
Issue Number	1
PubMed reference number	20056580
e-ISSN	15529924
DOI	10.1289/ehp.0900907
Language	English
Publisher	National Institute of Environmental Health Sciences
Publisher Date	2010-01-01
Access Restriction	Open
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Subject Keyword	air pollution lipid peroxidation M1dG adducts Map Ta Phut reactive oxygen species
Content Type	Text
Resource Type	Article
Subject	Health, Toxicology and Mutagenesis Public Health, Environmental and Occupational Health