Effect of ethanol extracts from red pepper seeds on antioxidative defense system and oxidative stress in rats fed high-fat . high-cholesterol diet.

Content Provider	Europe PMC
Author	Song, Won-Young Ku, Kyung-Hyung Choi, Jeong-Hwa
Copyright Year	2010
Abstract	The purpose of the present study was to investigate the effect of ethanol extracts from red pepper seeds on the antioxidative defense system and oxidative stress in rats fed a high fat · high cholesterol diet. Rats were divided into four experimental groups which were composed of high fat · high cholesterol diet group (HF), high fat · high cholesterol diet with 0.1% ethanol extracts from red pepper seeds supplemented group (HEA), high fat · high cholesterol diet with 0.2% ethanol extracts from red pepper seeds supplemented group (HEB) and high fat·high cholesterol diet with 0.5% ethanol extracts from red pepper seeds supplemented group (HEC). Supplementation of ethanol extracts from red pepper seeds groups (HEA, HEB and HEC) resulted in significantly increased activities of hepatic glutathione peroxidase and catalase. Hepatic superoxide radical contents in microsome and mitochondria were significantly reduced in the groups supplemented with red pepper seeds ethanol extracts. Hepatic hydrogen peroxide content in the mitochondria was reduced in ethanol extracts from red pepper seeds supplemented groups. TBARS values in the liver were reduced in red pepper seeds ethanol extracts supplemented groups. Especially, HEB and HEC groups were significantly decreased compared to the HF group. Hepatic carbonyl values were significantly reduced in mitochondria in these supplemented groups. These results suggest that red pepper seeds ethanol extracts may reduce oxidative damage, by activation of antioxidative defense system in rats fed high fat · high cholesterol diets.
ISSN	19761457
Journal	Nutrition Research and Practice
Volume Number	4
PubMed Central reference number	PMC2830408
Issue Number	1
PubMed reference number	20198203
e-ISSN	20056168
DOI	10.4162/nrp.2010.4.1.11
Language	English
Publisher	The Korean Nutrition Society and the Korean Society of Community Nutrition
Publisher Date	2010-02-24
Access Restriction	Open
Rights License	This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. ©2010 The Korean Nutrition Society and the Korean Society of Community Nutrition
Subject Keyword	Cholesterol red pepper seed extracts free radical oxidative stress antioxidative defense system
Content Type	Text
Resource Type	Article
Subject	Nutrition and Dietetics Food Science