NDLI: Kirkwood-Buff theory of molecular and protein association, aggregation, and cellular crowding.

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Kirkwood-Buff theory of molecular and protein association, aggregation, and cellular crowding.

Content Provider	Europe PMC
Author	Gee, Moon Bae Smith, Paul E.
Copyright Year	2009
Abstract	An analysis of the effect of a cosolvent on the association of a solute in solution using the Kirkwood–Buff theory of solutions is presented. The approach builds on the previous results of Ben-Naim by extending the range of applicability to include any number of components at finite concentrations in both closed and semiopen systems. The derived expressions, which are exact, provide a foundation for the analysis and rationalization of cosolvent effects on molecular and biomolecular equilibria including protein association, aggregation, and cellular crowding. A slightly different view of cellular crowding is subsequently obtained. In particular, it is observed that the addition of large cosolvents still favors the associated form even when traditional excluded volume effects are absent.
Related Links	https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC2780464&blobtype=pdf
ISSN	00219606
Volume Number	131
DOI	10.1063/1.3253299
PubMed Central reference number	PMC2780464
Issue Number	16
PubMed reference number	19894976
Journal	The Journal of Chemical Physics [J Chem Phys]
e-ISSN	10897690
Language	English
Publisher	American Institute of Physics
Publisher Date	2009-10-01
Access Restriction	Open
Rights License	Copyright © 2009 American Institute of Physics
Content Type	Text
Resource Type	Article
Subject	Physics and Astronomy Medicine Physical and Theoretical Chemistry

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