The degrees of hepatocyte cytoplasmic expression of hepatitis B core antigen correlate with histologic activity of liver disease in the young patients with chronic hepatitis B infection.

Content Provider	Europe PMC
Author	Kim, Tae Hyeon Cho, Eun Young Oh, Hyo Jeong Choi, Chang Soo Kim, Ji Woong Moon, Heung Bae Kim, Haak Cheul
Copyright Year	2006
Abstract	Subcellular localizaton of HBcAg have been found to be related to the activity of liver disease and HBV replication. The aim of this study was to determine whether the degree of expression of HBcAg in the hepatocyte nucleus and cytoplasm reflects the level of viral replication and histological activity in chronic HBV infection. A total of 102 patients with biopsy proven chronic hepatitis B were included. There was a highly significant correlation between the levels of HBV DNA in serum and the degree of expression of HBcAg in the nucleus for HBeAg-positive(p=0.000) and negative patients(p=0.04). There was a highly significant, correlation between the degrees of expression of HBcAg in hepatocyte cytoplasm and histologic activities (p<0.01) for HBeAg-positive patients. The degrees of expression of HBcAg in the hepatocyte cytoplasm correlated positively with the lobular activities (p<0.01), but not correlated with the portal activity and fibrosis for HBeAg-negative patients. In conclusion, in the young patients with chronic B viral hepatitis, the degree of expression of HBcAg in the hepatocyte nucleus may affect viral load, and the degree of expression of HBcAg in the hepatocyte cytoplasm may affect histologic activities of liver disease.
ISSN	10118934
Volume Number	21
PubMed Central reference number	PMC2734004
Issue Number	2
PubMed reference number	16614514
Journal	Journal of Korean Medical Science [J. Korean Med. Sci]
e-ISSN	15986357
DOI	10.3346/jkms.2006.21.2.279
Language	English
Publisher	The Korean Academy of Medical Sciences
Publisher Date	2006-04-01
Access Restriction	Open
Rights License	This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. Copyright © 2006 The Korean Academy of Medical Sciences
Subject Keyword	Hepatitis B Core Antigen Hepatitis Be Antigens HBV DNA Hepatitits B virus
Content Type	Text
Resource Type	Article
Subject	Medicine