NDLI: Gliomatosis cerebri type II: two case reports.

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Gliomatosis cerebri type II: two case reports.

Content Provider	Europe PMC
Author	D’Urso, Pietro Ivo D’Urso, Oscar Fernando Marsigliante, Santo Storelli, Carlo Distante, Alessandro Sanguedolce, Francesca Cimmino, Antonia Luzi, Giuseppe Gianfreda, Cosimo Damiano Montinaro, Antonio Ciappetta, Pasqualino
Copyright Year	2009
Abstract	IntroductionTwo types of gliomatosis cerebri exist: Type I and Type II. We report the results of a histological and genetic study of two cases of gliomatosis cerebri Type II, correlating these results with therapy and prognosis.Case presentationTwo patients, a 52-year-old man (Patient 1) and a 76-year-old man (Patient 2) with gliomatosis cerebri II were admitted to our institution; they underwent surgical treatment and received radiotherapy and chemotherapy. At the 24-month follow-up, Patient 1 was still alive, while Patient 2 had died. The poor prognosis of Patient 2 was underlined by molecular analysis which showed that the angiogenesis related genes VCAM1 and VEGF were overexpressed, reflecting the high degree of neovascularization.ConclusionGenes involved in drug resistance and metallothioneins were highly expressed in Patient 2 and this, associated with unmethylated O6-methylguanine methyltransferase, can explain the lack of response to chemotherapy.
Journal	Journal of Medical Case Reports
Volume Number	3
PubMed Central reference number	PMC2726545
PubMed reference number	19830138
e-ISSN	17521947
DOI	10.4076/1752-1947-3-7225
Language	English
Publisher	Cases Network Ltd
Publisher Date	2009-06-15
Access Restriction	Open
Rights License	This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. © 2009 D’Urso et al.; licensee Cases Network Ltd.
Content Type	Text
Resource Type	Article
Subject	Medicine

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