Metallo-beta-lactamase-producing Pseudomonas spp. in Korea: high prevalence of isolates with VIM-2 type and emergence of isolates with IMP-1 type.

Content Provider	Europe PMC
Author	Lee, Kyungwon Park, Ae Ja Kim, Moon Yeun Lee, Hee Joo Cho, Ji-Hyun Kang, Jung Oak Yong, Dongeun Chong, Yunsop
Copyright Year	2009
Abstract	PurposeTwo Korean nationwide studies showed that metallo-β-lactamases (MBLs)-producing-Pseudomonas spp. are not rare. The aim of this study was to assess the trends of MBL-producing isolates among imipenem-resistant isolates of Pseudomonas spp.Materials and MethodsImipenem-resistant clinical isolates were collected from 23 hospitals and one commercial laboratory participating in the KONSAR program in 2005. Polymerase chain reaction (PCR) was used to detect MBL genes.ResultsAlleles of MBL genes were detected in 10.8% of 415 Pseudomonas aeruginosa and 66.7% of 12 P. putida isolates from 18 of 24 hospitals/laboratory. Among the 14 IMP-1-like and 39 VIM-2-like MBLs, emergence of IMP-6 was detected for the first time.ConclusionPrevalence of MBL-producing P. aeruginosa has not significantly increased, but IMP-6 emerged in P. aeruginosa.
ISSN	05135796
Volume Number	50
PubMed Central reference number	PMC2703754
Issue Number	3
PubMed reference number	19568593
Journal	Yonsei Medical Journal [Yonsei Med. J]
e-ISSN	19762437
DOI	10.3349/ymj.2009.50.3.335
Language	English
Publisher	Yonsei University College of Medicine
Publisher Date	2009-06-23
Access Restriction	Open
Rights License	This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited. © Copyright: Yonsei University College of Medicine 2009
Subject Keyword	IMP-1 IMP-6 VIM-2 metallo-β-lactamase Korea
Content Type	Text
Resource Type	Article
Subject	Medicine