Epigenetic regulation of cytokine gene expression in T lymphocytes.

Content Provider	Europe PMC
Author	Lee, Choong-Gu Sahoo, Anupama Im, Sin-Hyeog
Copyright Year	2009
Abstract	The developmental program of T helper and regulatory T cell lineage commitment is governed by both genetic and epigenetic mechanisms. The principal events, signaling pathways and the lineage determining factors involved have been extensively studied in the past ten years. Recent studies have elucidated the important role of chromatin remodeling and epigenetic changes for proper regulation of gene expression of lineage-specific cytokines. These include DNA methylation and histone modifications in epigenomic reprogramming during T helper cell development and effector T cell functions. This review discusses the basic epigenetic mechanisms and the role of transcription factors for the differential cytokine gene regulation in the T helper lymphocyte subsets.
ISSN	05135796
Volume Number	50
PubMed Central reference number	PMC2703752
Issue Number	3
PubMed reference number	19568591
Journal	Yonsei Medical Journal [Yonsei Med. J]
e-ISSN	19762437
DOI	10.3349/ymj.2009.50.3.322
Language	English
Publisher	Yonsei University College of Medicine
Publisher Date	2009-06-23
Access Restriction	Open
Rights License	This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited. © Copyright: Yonsei University College of Medicine 2009
Subject Keyword	Epigenetics cytokine T lymphocytes gene regulation
Content Type	Text
Resource Type	Article
Subject	Medicine