Microsatellite marker in gamma - aminobutyric acid - a receptor beta 3 subunit gene and autism spectrum disorders in Korean trios.

Content Provider	Europe PMC
Author	Yoo, Hanik K. Chung, Seockhoon Hong, Jin Pyo Kim, Boong-Nyun Cho, Soo Churl
Copyright Year	2009
Abstract	This study aimed to identify the association between gamma-aminobutyric acid-A (GABA-A) receptor subunit β3 (GABRB3) gene and autism spectrum disorders (ASD) in Korea. Fifty-eight children with ASD [47 boys (81.0%), 5.5 ± 4.1 years old], 46 family trios, and 86 healthy control subjects [71 males (82.6%), 33.6 ± 9.3 years old] were recruited. Transmission disequilibrium test revealed that, 183 bp long allele in GABRB3 gene was preferentially transmitted in families with ASD (p = 0.025), whereas a population-based case-control study, however, showed no association between ASD and GABRB3 microsatellite polymorphism. Our data provide preliminary evidence that GABRB3 gene is associated with ASD in Korea.
ISSN	05135796
Volume Number	50
PubMed Central reference number	PMC2678711
Issue Number	2
PubMed reference number	19430570
Journal	Yonsei Medical Journal [Yonsei Med. J]
e-ISSN	19762437
DOI	10.3349/ymj.2009.50.2.304
Language	English
Publisher	Yonsei University College of Medicine
Publisher Date	2009-04-01
Access Restriction	Open
Rights License	This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited. © Copyright: Yonsei University College of Medicine 2009
Subject Keyword	Autism spectrum disorders genetics transmission disequilibrium test microsatellite gamma-aminobutyric acid-A receptor subunit β3
Content Type	Text
Resource Type	Article
Subject	Medicine