NDLI: Assessment of cerebrovascular reserve before and after STA-MCA bypass surgery by SPECT and SPM analysis.

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Assessment of cerebrovascular reserve before and after STA-MCA bypass surgery by SPECT and SPM analysis.

Content Provider	Europe PMC
Author	O, Joo-Hyun Jang, Kyung-Sool Yoo, Ie-Ryung Kim, Sung-Hoon Chung, Soo-Kyo Sohn, Hyung-Sun Rha, Hyung-Kyun Park, Hae-Kwan Chung, Yong-An Jeong, Jaeseung
Copyright Year	2007
Abstract	ObjectiveThe purpose of this study was to objectively assess the efficacy of superficial temporal artery to middle cerebral artery (STA-MCA) bypass surgery using Technetium (Tc)-99m-ethyl cysteinate dimer (ECD) single photon emission computed tomography (SPECT) in patients who underwent STA-MCA bypass surgery.Materials and MethodsBrain perfusion SPECT images obtained at baseline and after the administration of acetazolamide were reconstructed using statistical parametric mapping in 23 patients, both before and after STA-MCA bypass surgery. The clinical outcomes of the surgery were also recorded and compared with the hemodynamic changes. A voxel with an uncorrected p-value of less than 0.001 was considered to be statistically significant.ResultsSPECT images of the territory supplied by the bypass graft showed an increase in both cerebrovascular flow and reserve at baseline, and the increase was significantly higher following the administration of acetazolamide. All patients showed improvement of clinical symptoms and increased blood flow to the left temporal, parietal, and frontal cortices as well as the thalamus.ConclusionBrain SPECT effectively and objectively demonstrated the improved outcomes of STA-MCA bypass surgery, and thus may be used in postoperative analyses.
ISSN	12296929
Journal	Korean Journal of Radiology
Volume Number	8
PubMed Central reference number	PMC2637131
Issue Number	6
PubMed reference number	18071275
e-ISSN	20058330
DOI	10.3348/kjr.2007.8.6.458
Language	English
Publisher	The Korean Radiological Society
Publisher Date	2007-11-01
Access Restriction	Open
Rights License	This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. Copyright © 2007 The Korean Radiological Society
Subject Keyword	Cerebral revascularization STA-MCA bypass SPECT, Tc-99m-ECD
Content Type	Text
Resource Type	Article
Subject	Radiology, Nuclear Medicine and Imaging

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