FDG-PET for evaluating the antitumor effect of intraarterial 3-bromopyruvate administration in a rabbit VX2 liver tumor model.

Content Provider	Europe PMC
Author	Park, Hee Sun Chung, Jin Wook Jae, Hwan Jun Kim, Young Il Son, Kyu Ri Lee, Min Jong Park, Jae Hyung Kang, Won Jun Yoon, Jung Hwan Chung, Hesson Lee, Kichang
Copyright Year	2007
Abstract	ObjectiveWe wanted to investigate the feasibility of using FDG-PET for evaluating the antitumor effect of intraarterial administration of a hexokinase II inhibitor, 3-bromopyruvate (3-BrPA), in a rabbit VX2 liver tumor model.Materials and MethodsVX2 carcinoma was grown in the livers of ten rabbits. Two weeks later, liver CT was performed to confirm appropriate tumor growth for the experiment. After tumor volume-matched grouping of the rabbits, transcatheter intraarterial administration of 3-BrPA was performed (1 mM and 5 mM in five animals each, respectively). FDG-PET scan was performed the day before, immediately after and a week after 3-BrPA administration. FDG uptake was semiquantified by measuring the standardized uptake value (SUV). A week after treatment, the experimental animals were sacrificed and the necrosis rates of the tumors were calculated based on the histopathology.ResultsThe SUV of the VX2 tumors before treatment (3.87 ±1.51 [mean ±SD]) was significantly higher than that of nontumorous liver parenchyma (1.72 ±0.34) (p < 0.0001, Mann-Whitney U test). The SUV was significantly decreased immediately after 3-BrPA administration (2.05 ±1.21) (p = 0.002, Wilcoxon signed rank test). On the one-week follow up PET scan, the FDG uptake remained significantly lower (SUV 1.41 ±0.73) than that before treatment (p = 0.002), although three out of ten animals showed a slightly increasing tendency for the FDG uptake. The tumor necrosis rate ranged from 50.00% to 99.90% (85.48% ±15.87). There was no significant correlation between the SUV or the SUV decrease rate and the tumor necrosis rate in that range.ConclusionEven though FDG-PET cannot exactly reflect the tumor necrosis rate, FDG-PET is a useful modality for the early assessment of the antitumor effect of intraarterial administration of 3-BrPA in VX2 liver tumor.
ISSN	12296929
Journal	Korean Journal of Radiology
Volume Number	8
PubMed Central reference number	PMC2627418
Issue Number	3
PubMed reference number	17554189
e-ISSN	20058330
DOI	10.3348/kjr.2007.8.3.216
Language	English
Publisher	The Korean Radiological Society
Publisher Date	2007-05-01
Access Restriction	Open
Rights License	This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. Copyright © 2007 The Korean Radiological Society
Subject Keyword	Liver neoplasm, therapeutic radiology Liver, interventional procedure Liver, PET
Content Type	Text
Resource Type	Article
Subject	Radiology, Nuclear Medicine and Imaging