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Carrageenan inhibits granzyme A-induced detachment of and interleukin-8 release from alveolar epithelial A549 cells.
| Content Provider | Europe PMC |
|---|---|
| Author | Yoshikawa, Yumiko Hirayasu, Hirofumi Tsuzuki, Satoshi Fushiki, Tohru |
| Abstract | Granzyme A (GrA) is a lymphocyte serine protease that is believed to enter virus-infected cells and growing tumors and induce apoptosis. We found recently that recombinant rat GrA (rGrA) promotes detachment of and interleukin (IL)-8 release from alveolar epithelial A549 cells and suggested that this protease is involved in the pathogenesis of certain inflammatory lung diseases. In the present study, we found that λ-carrageenan (a sulfated oligosaccharide constituting the cell walls of seaweeds) potently inhibits rGrA-induced detachment and IL-8 release of A549 cells. This sulfated oligosaccharide might be useful for suppressing the development of inflammatory lung diseases in which GrA is thought to be involved. |
| Related Links | https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC2612106&blobtype=pdf |
| ISSN | 09209069 |
| Volume Number | 58 |
| DOI | 10.1007/s10616-008-9175-7 |
| PubMed Central reference number | PMC2612106 |
| Issue Number | 2 |
| PubMed reference number | 19002766 |
| Journal | Cytotechnology |
| e-ISSN | 15730778 |
| Language | English |
| Publisher | Springer Netherlands |
| Publisher Date | 2008-10-01 |
| Publisher Place | Dordrecht |
| Access Restriction | Open |
| Rights License | © Springer Science+Business Media B.V. 2008 |
| Subject Keyword | A549 cells Carrageenan Detachment Granzyme A Interleukin-8 release |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Clinical Biochemistry Bioengineering Biomedical Engineering Biotechnology |
