NDLI: Mitochondrial DNA aberrations of bone marrow cells from patients with aplastic anemia.

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Mitochondrial DNA aberrations of bone marrow cells from patients with aplastic anemia.

Content Provider	Europe PMC
Author	Kim, Hye-Ran Shin, Myung-Geun Kim, Mi-Ji Kim, Hyeoung-Joon Shin, Jong-Hee Suh, Soon-Pal Ryang, Dong-Wook
Copyright Year	2008
Abstract	This study was undertaken primarily to test the hypothesis that mitochondrial DNA (mtDNA) mutations may be associated with aplastic anemia. Complete mtDNA nucleotide sequence was analyzed in nine and eight bone marrow specimens from Korean patients with aplastic anemia and healthy individuals, respectively. We found a large number of polymorphisms as well as apparent new mutations in both patients and controls throughout the entire mtDNA genome; 12 mutations harbored amino acid changes in patients and none of the mutations in controls produced amino acid changes. There were heteroplasmic mutations and more nonsynonymous mtDNA changes observed in patients, so the mean number of mtDNA aberrations of bone marrow cells showed statistically significant difference overall between patients (mean=25.6) and controls (mean=12.8) (p=0.019). Our data may support an association of mtDNA aberrations with aplastic anemia.
ISSN	10118934
Volume Number	23
PubMed Central reference number	PMC2610644
Issue Number	6
PubMed reference number	19119453
Journal	Journal of Korean Medical Science [J. Korean Med. Sci]
e-ISSN	15986357
DOI	10.3346/jkms.2008.23.6.1062
Language	English
Publisher	The Korean Academy of Medical Sciences
Publisher Date	2008-12-24
Access Restriction	Open
Rights License	This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. Copyright © 2008 The Korean Academy of Medical Sciences
Subject Keyword	Anemia, Aplastic DNA, Mitochondrial Mutation
Content Type	Text
Resource Type	Article
Subject	Medicine

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