NDLI: The effect of geometry on three-dimensional tissue growth.

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The effect of geometry on three-dimensional tissue growth.

Content Provider	Europe PMC
Author	Rumpler, Monika Woesz, Alexander Dunlop, John W.C van Dongen, Joost T Fratzl, Peter
Copyright Year	2008
Abstract	Tissue formation is determined by uncountable biochemical signals between cells; in addition, physical parameters have been shown to exhibit significant effects on the level of the single cell. Beyond the cell, however, there is still no quantitative understanding of how geometry affects tissue growth, which is of much significance for bone healing and tissue engineering. In this paper, it is shown that the local growth rate of tissue formed by osteoblasts is strongly influenced by the geometrical features of channels in an artificial three-dimensional matrix. Curvature-driven effects and mechanical forces within the tissue may explain the growth patterns as demonstrated by numerical simulation and confocal laser scanning microscopy. This implies that cells within the tissue surface are able to sense and react to radii of curvature much larger than the size of the cells themselves. This has important implications towards the understanding of bone remodelling and defect healing as well as towards scaffold design in bone tissue engineering.
ISSN	17425689
Journal	Journal of the Royal Society Interface
Volume Number	5
PubMed Central reference number	PMC2495039
Issue Number	27
PubMed reference number	18348957
e-ISSN	17425662
DOI	10.1098/rsif.2008.0064
Language	English
Publisher	The Royal Society
Publisher Date	2008-10-01
Publisher Place	London
Access Restriction	Open
Rights License	This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Copyright © 2008 The Royal Society
Subject Keyword	three-dimensional tissue formation scaffold channels bone tissue engineering curvature-driven growth osteoblasts
Content Type	Text
Resource Type	Article
Subject	Biomaterials Biochemistry Biophysics Bioengineering Biomedical Engineering Biotechnology

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