Adenomatous polyposis coli (APC) gene promoter hypermethylation in primary breast cancers.

Content Provider	Europe PMC
Author	Jin, Z Tamura, G Tsuchiya, T Sakata, K Kashiwaba, M Osakabe, M Motoyama, T
Copyright Year	2001
Abstract	Similar to findings in colorectal cancers, it has been suggested that disruption of the adenomatous polyposis coli (APC)/β-catenin pathway may be involved in breast carcinogenesis. However, somatic mutations of APC and β- catenin are infrequently reported in breast cancers, in contrast to findings in colorectal cancers. To further explore the role of the APC/β-catenin pathway in breast carcinogenesis, we investigated the status of APC gene promoter methylation in primary breast cancers and in their non-cancerous breast tissue counterparts, as well as mutations of the APC and β- catenin genes. Hypermethylation of the APC promoter CpG island was detected in 18 of 50 (36%) primary breast cancers and in none of 21 non-cancerous breast tissue samples, although no mutations of the APC and β- catenin were found. No significant associations between APC promoter hypermethylation and patient age, lymph node metastasis, oestrogen and progesterone receptor status, size, stage or histological type of tumour were observed. These results indicate that APC promoter CpG island hypermethylation is a cancer-specific change and may be a more common mechanism of inactivation of this tumour suppressor gene in primary breast cancers than previously suspected. © 2001 Cancer Research Campaign http://www.bjcancer.com
ISSN	00070920
Journal	British Journal of Cancer
Volume Number	85
PubMed Central reference number	PMC2363914
Issue Number	1
PubMed reference number	11437404
e-ISSN	15321827
DOI	10.1054/bjoc.2001.1853
Language	English
Publisher	Nature Publishing Group
Publisher Date	2001-07-01
Access Restriction	Open
Rights License	This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/. Copyright © 2001 Cancer Research Campaign
Subject Keyword	hypermethylation APC breast cancer methylation-specific PCR
Content Type	Text
Resource Type	Article
Subject	Cancer Research Oncology