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Compliance with guidelines is related to better local recurrence-free survival in ductal carcinoma in situ.
| Content Provider | Europe PMC |
|---|---|
| Author | de Roos, M A J de Bock, G H Baas, P C de Munck, L Wiggers, T de Vries, J |
| Copyright Year | 2005 |
| Abstract | The aim was to study the effect of compliance with guidelines on local recurrence (LR)-free survival in patients treated for ductal carcinoma in situ (DCIS). From January 1992 to December 2003, 251 consecutive patients had been treated for DCIS in two hospitals in the North Netherlands. Every case in this two-hospital sample was reviewed in retrospect for its clinical and pathological parameters. It was determined whether treatment had been carried out according to clinical guidelines, and outcomes in follow-up were assessed. In addition, all patients treated for DCIS in this region (n=1389) were studied regarding clinical parameters, in order to determine whether the two-hospital sample was representative of the entire region. In the two-hospital sample, 31.4% (n=79) of the patients had not been treated according to the guidelines. Positive margins were associated with LR (hazard ratio (HR)=4.790, 95% confidence interval (CI) 1.696–13.531). Breast-conserving surgery and deviation from the guidelines were independent predictors of LR (HR=7.842, 95% CI 2.126–28.926; HR=2.778, 95% CI 0.982–6.781, respectively). Although the guidelines changed over time, time was not a significant factor in predicting LRs (HR=1.254, 95% CI 0.272–5.776 for time period 1992–1995 and HR=1.976, 95% CI 0.526–7.421 for time period 1996–1999). Clinical guidelines for the treatment of patients with DCIS have been developed and updated from existing literature and best evidence. Compliance with the guidelines was an independent predictor of disease-free survival. These findings support the application of guidelines in the treatment of DCIS. |
| ISSN | 00070920 |
| Journal | British Journal of Cancer |
| Volume Number | 93 |
| PubMed Central reference number | PMC2361497 |
| Issue Number | 10 |
| PubMed reference number | 16234825 |
| e-ISSN | 15321827 |
| DOI | 10.1038/sj.bjc.6602815 |
| Language | English |
| Publisher | Nature Publishing Group |
| Publisher Date | 2005-11-01 |
| Access Restriction | Open |
| Rights License | This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material.If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/. Copyright © 2005 Cancer Research UK |
| Subject Keyword | breast neoplasm ductal carcinoma in situ clinical guidelines breast-conserving surgery mastectomy local neoplasm recurrence |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cancer Research Oncology |
