NDLI: Genetic susceptibility to infectious diseases: big is beautiful, but will bigger be even better?

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Genetic susceptibility to infectious diseases: big is beautiful, but will bigger be even better?

Content Provider	Europe PMC
Author	Burgner, David Jamieson, Sarra E Blackwell, Jenefer M
Copyright Year	2006
Abstract	SummaryGenetic epidemiology, including twin studies, provides robust evidence that genetic variation in human populations contributes to susceptibility to infectious disease. One of the major limitations of studies that attempt to identify the genes and mechanisms that underlie this susceptibility has been lack of power caused by small sample size. With the development of novel technologies, burgeoning information on the human genome, the HapMap project, and human genetic diversity, we are at the beginning of a new era in the study of the genetics of complex diseases. This review looks afresh at the epidemiological evidence that supports a role for genetics in susceptibility to infectious disease, examines the somewhat limited achievements to date, and discusses current advances in methodology and technology that will potentially lead to translational data in the future.
ISSN	14733099
Journal	The Lancet. Infectious Diseases
Volume Number	6
PubMed Central reference number	PMC2330096
Issue Number	10
PubMed reference number	17008174
e-ISSN	14744457
DOI	10.1016/S1473-3099(06)70601-6
Language	English
Publisher	Elsevier Ltd.
Publisher Date	2006-10-01
Access Restriction	Open
Rights License	Since January 2020 Elsevier has created a COVID-19 resource centre with free information in English and Mandarin on the novel coronavirus COVID-19. The COVID-19 resource centre is hosted on Elsevier Connect, the company's public news and information website. Elsevier hereby grants permission to make all its COVID-19-related research that is available on the COVID-19 resource centre - including this research content - immediately available in PubMed Central and other publicly funded repositories, such as the WHO COVID database with rights for unrestricted research re-use and analyses in any form or by any means with acknowledgement of the original source. These permissions are granted for free by Elsevier for as long as the COVID-19 resource centre remains active. Copyright © 2006 Elsevier Ltd.
Content Type	Text
Resource Type	Article
Subject	Infectious Diseases

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