NDLI: Antitumour activity of adenovirus-12 structural proteins against Moloney sarcoma tumours in mice.

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Antitumour activity of adenovirus-12 structural proteins against Moloney sarcoma tumours in mice.

Content Provider	Europe PMC
Author	Abid, S. H. Khoobyarian, N.
Abstract	When purified fibre and hexon proteins of adenovirus 12 were given intramuscularly to 4-week-old BALB/c mice (250-300 mug/mouse) 2 h prior to inoculation with mouse sarcoma virus (0.05 ml of 10(4) FFU/ml) at the same site, significant suppression of tumour growth (P less than 0.001), and rapid regression in tumour size (P less than 0.001) were noted. As a rule, the survival rate in treated mice was also significantly higher than in untreated mice. Furthermore, the disease process in treated mice as compared to untreated mice was far less extensive as judged by the scarcity of sarcoma lesions on the spleens. Preliminary evidence suggested that treatment with fibre could lead to increased cellular immunity in mice. Whether this may be a secondary consequence of events whereby fibre inhibited tumour growth rather than first order mechanism of the inhibition is not known.ImagesFig. 1
ISSN	00070920
Journal	British Journal of Cancer
Volume Number	33
PubMed Central reference number	PMC2025084
Issue Number	4
PubMed reference number	1268030
e-ISSN	15321827
DOI	10.1038/bjc.1976.63
Language	English
Publisher	Nature Publishing Group
Publisher Date	1976-04-01
Access Restriction	Open
Rights License	This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit https://creativecommons.org/licenses/by/4.0/.
Content Type	Text
Resource Type	Article
Subject	Cancer Research Oncology

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