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Exposure to phthalates in neonatal intensive care unit infants: urinary concentrations of monoesters and oxidative metabolites.
| Content Provider | Europe PMC |
|---|---|
| Author | Weuve, Jennifer Sánchez, Brisa N. Calafat, Antonia M. Schettler, Ted Green, Ronald A. Hu, Howard Hauser, Russ |
| Copyright Year | 2006 |
| Abstract | ObjectiveWe previously demonstrated that among 54 infants in neonatal intensive care units, exposure to polyvinyl chloride plastic medical devices containing the plasticizer di(2-ethylhexyl) phthalate (DEHP) is associated with urinary concentrations of mono(2-ethylhexyl) phthalate (MEHP), a DEHP metabolite. In this follow-up report, we studied the neonates’ exposure to DEHP-containing devices in relation to urinary concentrations of two other DEHP metabolites, and to urinary concentrations of metabolites of dibutyl phthalate (DBP) and benzylbutyl phthalate (BzBP), phthalates found in construction materials and personal care products.MeasurementsA priori, we classified the intensiveness of these 54 infants’ exposure to DEHP-containing medical products. We measured three metabolites of DEHP in infants’ urine: MEHP and two of its oxidative metabolites, mono(2-ethyl-5-hydroxylhexyl) phthalate (MEHHP) and mono(2-ethyl-5-oxohexyl) phthalate (MEOHP). We also measured monobutyl phthalate (MBP), a metabolite of DBP, and monobenzyl phthalate (MBzP), a metabolite of BzBP.ResultsIntensiveness of DEHP-containing product use was monotonically associated with all three DEHP metabolites. Urinary concentrations of MEHHP and MEOHP among infants in the high-DEHP-intensiveness group were 13–14 times the concentrations among infants in the low-intensiveness group (p ≤ 0.007). Concentrations of MBP were somewhat higher in the medium-and high-DEHP-intensiveness group; MBzP did not vary by product use group. Incorporating all phthalate data into a structural equation model confirmed the specific monotonic association between intensiveness of product use and biologic measures of DEHP.ConclusionInclusion of the oxidative metabolites MEHHP and MEOHP strengthened the association between intensiveness of product use and biologic indices of DEHP exposure over that observed with MEHP alone. |
| ISSN | 00916765 |
| Journal | Environmental Health Perspectives |
| Volume Number | 114 |
| PubMed Central reference number | PMC1570064 |
| Issue Number | 9 |
| PubMed reference number | 16966100 |
| e-ISSN | 15529924 |
| DOI | 10.1289/ehp.8926 |
| Language | English |
| Publisher | National Institute of Environmental Health Sciences |
| Publisher Date | 2006-09-01 |
| Access Restriction | Open |
| Rights License | Publication of EHP lies in the public domain and is therefore without copyright. All text from EHP may be reprinted freely. Use of materials published in EHP should be acknowledged (for example, ?Reproduced with permission from Environmental Health Perspectives?); pertinent reference information should be provided for the article from which the material was reproduced. Articles from EHP, especially the News section, may contain photographs or illustrations copyrighted by other commercial organizations or individuals that may not be used without obtaining prior approval from the holder of the copyright. |
| Subject Keyword | di(2-ethylhexyl) phthalate (DEHP) infants mono(2-ethylhexyl) phthalate (MEHP) mono(2-ethyl-5-hydroxylhexyl) phthalate (MEHHP) mono(2-ethyl-5-oxohexyl) phthalate (MEOHP) monobenzyl phthalate (MBzP) monobutyl phthalate (MBP) neonatal intensive care unit (NICU) phthalate structural equation model |
| Content Type | Text |
| Resource Type | Article |
| Subject | Health, Toxicology and Mutagenesis Public Health, Environmental and Occupational Health |
