NDLI: Correlation of cytokine gene expression with pathology in white-tailed deer (Odocoileus virginianus) infected with Mycobacterium bovis.

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Correlation of cytokine gene expression with pathology in white-tailed deer (Odocoileus virginianus) infected with Mycobacterium bovis.

Content Provider	Europe PMC
Author	Thacker, Tyler C. Palmer, Mitchell V. Waters, W. Ray
Abstract	Mycobacterium bovis-infected white-tailed deer (WTD) in northeast Michigan are a reservoir of mycobacteria that pose a threat to both domestic animals and humans. Relatively little work has been done to characterize the immune response of WTD to M. bovis infection; however, an understanding of the immune response to infection and pathogenesis may be critical to the development of an effective vaccine. Immunological responses to infection were characterized by monitoring cytokine gene expression in M. bovis-infected and uninfected deer. Peripheral blood leukocytes (PBL) from infected WTD expressed more gamma interferon (IFN-γ), interleukin-12p40 (IL-12p40), granulocyte-monocyte colony-stimulating factor, and IL-4 mRNA than did PBL from uninfected deer; however, differences were not detected in expression of IL-10 and transforming growth factor-β mRNA. Infected animals could be divided into two groups based on pathology. Lesions were confined primarily to the lymph nodes of the head in animals with less severe pathology. Animals with more severe pathology had lesions in the lung and associated lymph nodes as well as the lymph nodes of the head. More robust IFN-γ mRNA expression correlated with pathology early in infection. These findings indicate that IFN-γ expression likely plays a role in both protection and pathogenesis.
Related Links	https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC1489556&blobtype=pdf
ISSN	15566811
Volume Number	13
PubMed Central reference number	PMC1489556
Issue Number	6
PubMed reference number	16760321
Journal	Clin Vaccine Immunol
e-ISSN	1556679X
DOI	10.1128/cvi.00024-06
Language	English
Publisher	American Society for Microbiology
Publisher Date	2006-06-01
Access Restriction	Open
Content Type	Text
Resource Type	Article
Subject	Immunology and Allergy Clinical Biochemistry Immunology Microbiology (medical)

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