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Microwaves from GSM mobile telephones affect 53BP1 and gamma-H2AX foci in human lymphocytes from hypersensitive and healthy persons.
| Content Provider | Europe PMC |
|---|---|
| Author | Markovà, Eva Hillert, Lena Malmgren, Lars Persson, Bertil R. R. Belyaev, Igor Y. |
| Copyright Year | 2005 |
| Abstract | The data on biologic effects of nonthermal microwaves (MWs) from mobile telephones are diverse, and these effects are presently ignored by safety standards of the International Commission for Non-Ionizing Radiation Protection (ICNIRP). In the present study, we investigated effects of MWs of Global System for Mobile Communication (GSM) at different carrier frequencies on human lymphocytes from healthy persons and from persons reporting hypersensitivity to electromagnetic fields (EMFs). We measured the changes in chromatin conformation, which are indicative of stress response and genotoxic effects, by the method of anomalous viscosity time dependence, and we analyzed tumor suppressor p53-binding protein 1 (53BP1) and phosphorylated histone H2AX (γ-H2AX), which have been shown to colocalize in distinct foci with DNA double-strand breaks (DSBs), using immunofluorescence confocal laser microscopy. We found that MWs from GSM mobile telephones affect chromatin conformation and 53BP1/γ-H2AX foci similar to heat shock. For the first time, we report here that effects of MWs from mobile telephones on human lymphocytes are dependent on carrier frequency. On average, the same response was observed in lymphocytes from hypersensitive and healthy subjects. |
| ISSN | 00916765 |
| Journal | Environmental Health Perspectives |
| Volume Number | 113 |
| PubMed Central reference number | PMC1280397 |
| Issue Number | 9 |
| PubMed reference number | 16140623 |
| e-ISSN | 15529924 |
| DOI | 10.1289/ehp.7561 |
| Language | English |
| Publisher | National Institute of Environmental Health Sciences |
| Publisher Date | 2005-09-01 |
| Access Restriction | Open |
| Rights License | Publication of EHP lies in the public domain and is therefore without copyright. All text from EHP may be reprinted freely. Use of materials published in EHP should be acknowledged (for example, ?Reproduced with permission from Environmental Health Perspectives?); pertinent reference information should be provided for the article from which the material was reproduced. Articles from EHP, especially the News section, may contain photographs or illustrations copyrighted by other commercial organizations or individuals that may not be used without obtaining prior approval from the holder of the copyright. |
| Subject Keyword | 53BP1 and γ-H2AX foci chromatin DNA double-strand breaks hypersensitivity to electromagnetic fields stress response |
| Content Type | Text |
| Resource Type | Article |
| Subject | Health, Toxicology and Mutagenesis Public Health, Environmental and Occupational Health |
