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Negative Symptoms and Their Associations With Other Clinical Variables and Working Memory Across the Schizophrenia Spectrum and Bipolar Disorder.
| Content Provider | Europe PMC |
|---|---|
| Author | De Pieri, Marco Berg, Xaver Georgiadis, Foivos Brakowski, Janis Burrer, Achim Sabé, Michel Kaliuzhna, Mariia Vetter, Stefan Seifritz, Erich Homan, Philipp Kaiser, Stefan Kirschner, Matthias |
| Copyright Year | 2024 |
| Abstract | AbstractNegative symptoms (NS) of schizophrenia spectrum disorders (SSD) are also prevalent in bipolar disorder I (BD-I) and show associations with impaired working memory (WM). However, empirical work on their relationship to other clinical factors across SSD and BD-I is sparse. Here, we characterized the associations of NS with key clinical variables and WM capacity across a combined sample of SSD and BD. We included 50 outpatients with SSD and 49 with BD-I and assessed NS domains using SANS global scores for avolition-apathy, anhedonia-asociality, alogia, and blunted affect. We assessed the transdiagnostic relationship between NS and other clinical variables, including positive symptoms, disorganization, depressive symptoms, and antipsychotic medication, using multiple regressions. The strength of these associations was further determined through dominance analyses. Finally, we used multiple regression to assess the relationship between NS domains and WM. To assess the generalizability of transdiagnostic associations, analyses were repeated in each diagnostic group separately. Across SSD and BD-I, disorganization was associated with avolition-apathy and anhedonia-asociality and depressive symptoms additionally predicted anhedonia-asociality. Antipsychotic dose was associated with blunted affect while group differences only predicted alogia. Higher avolition-apathy was related to impaired WM transdiagnostically, partially mediated by the severity of disorganization, whereas only in BD-I higher anhedonia-asociality was associated with better WM capacity. This study demonstrated transdiagnostic associations of both avolition-apathy and anhedonia-asociality with disorganization and identified avolition-apathy as a potential transdiagnostic predictor of WM impairments. Overall, our findings highlight the importance of understanding the relationship between NS domains and other clinical factors with cognitive function across SSD and BD. |
| Related Links | https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC11487101&blobtype=pdf |
| Page Count | 12 |
| Volume Number | 5 |
| DOI | 10.1093/schizbullopen/sgae024 |
| PubMed Central reference number | PMC11487101 |
| Issue Number | 1 |
| PubMed reference number | 39430551 |
| Journal | Schizophrenia Bulletin Open [Schizophr Bull Open] |
| e-ISSN | 26327899 |
| Language | English |
| Publisher | Oxford University Press |
| Publisher Date | 2024-01-01 |
| Publisher Place | US |
| Access Restriction | Open |
| Rights License | This is an Open Access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited. © The Author(s) 2024. Published by Oxford University Press on behalf of the University of Maryland's school of medicine, Maryland Psychiatric Research Center. |
| Subject Keyword | negative symptoms apathy schizophrenia bipolar disorder working memory |
| Content Type | Text |
| Resource Type | Article |
| Subject | Psychiatry and Mental Health |
