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Diagnostic Accuracy of Lipase as Early Predictor of Postoperative Pancreatic Fistula: Results from the LIPADRAIN study.
| Content Provider | Europe PMC |
|---|---|
| Author | Doussot, Béranger Doussot, Alexandre Ayav, Ahmet Santucci, Nicolas Deguelte, Sophie Sow, Amadou Khalilou El Amrani, Mehdi Duvillard, Laurence Piessen, Guillaume Girard, Edouard Mabrut, Jean-Yves Garnier, Jonathan Ortega-Deballon, Pablo Fournel, Isabelle Facy, Olivier |
| Copyright Year | 2024 |
| Abstract | Objective:To evaluate the diagnostic accuracy of drain fluid lipase as an early predictor of postoperative pancreatic fistula and establish the most appropriate day for their measure.Background:Clinically relevant postoperative pancreatic fistula remains a potentially life-threatening complication after pancreatic surgery. Early detection strategies remain key to reduce both the incidence and the burden of pancreatic fistula.Methods:The LIPAse DRAIN (LIPADRAIN) study is a multicenter, prospective diagnostic study conducted in 7 tertiary university hospitals. Drain fluid values to detect clinically relevant postoperative pancreatic fistula from postoperative day 1 to postoperative day 6 were evaluated using receiver operating characteristic curve analysis. A biomarker was considered to be relevant for clinical use if its area under the curve (AUC) was greater than 0.75.Results:Of the 625 patients included in the analysis, clinically relevant postoperative pancreatic fistula occurred in 203 (32%) patients. On postoperative days 3 and 4, drain fluid lipase was a reliable biomarker to detect clinically relevant postoperative pancreatic fistula (AUC: 0.761; 95% confidence interval [CI]: 0.761–0.799 and AUC: 0.784; 95% CI: 0.743–0.821, respectively). On postoperative day 3, with a threshold of 299 units/L, drain fluid lipase yielded a negative predictive value of 51%, sensitivity of 78%, and specificity of 63% for the detection of clinically relevant postoperative pancreatic fistula.Conclusions:In this multicenter prospective study, drain fluid lipase is a reliable biomarker at postoperative days 3 and 4 for the diagnosis of clinically relevant postoperative pancreatic fistula after pancreatic surgery and should be systematically measured on postoperative day 3. |
| Related Links | https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC11415086&blobtype=pdf |
| Volume Number | 5 |
| PubMed Central reference number | PMC11415086 |
| Issue Number | 3 |
| PubMed reference number | 39310332 |
| Journal | Annals of Surgery Open [Ann Surg Open] |
| e-ISSN | 26913593 |
| DOI | 10.1097/as9.0000000000000492 |
| Language | English |
| Publisher | Wolters Kluwer Health, Inc. |
| Publisher Date | 2024-09-11 |
| Publisher Place | Philadelphia |
| Access Restriction | Open |
| Rights License | This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. Copyright © 2024 The Author(s). Published by Wolters Kluwer Health, Inc. |
| Subject Keyword | Clinically relevant postoperative pancreatic fistula Drain fluid lipase Drain fluid amylase |
| Content Type | Text |
| Resource Type | Article |
| Subject | Surgery |
