Surgical Decision-Making in Familial Adenomatous Polyposis.

Content Provider	Europe PMC
Author	Steinberger, Allie E. Westfal, Maggie L. Wise, Paul E.
Copyright Year	2023
Abstract	Familial adenomatous polyposis (FAP) is an autosomal dominant disorder affecting patients with germline mutations of the adenomatous polyposis coli (APC) tumor suppressor gene. The surgical treatment of colorectal disease in FAP, which has the goal of colorectal cancer prevention, varies based on both patient and disease factors but can include the following: total colectomy with ileorectal anastomosis, proctocolectomy with stapled or hand-sewn ileal pouch-anal anastomosis, or total proctocolectomy with end ileostomy. The operative options and extent of resection, as well as the use of endoscopy and chemoprevention for the management of polyposis, will be discussed in detail in this article. In addition, commonly debated management decisions related to the treatment of patients with FAP, including the timing of prophylactic colorectal resections for patients with FAP and management of the polyp burden in the rectum, will be discussed. Finally, genotype considerations and the impact of desmoid disease on operative decisions in the setting of FAP will also be reviewed.
Related Links	https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC11007598&blobtype=pdf
ISSN	15310043
Volume Number	37
DOI	10.1055/s-0043-1770732
PubMed Central reference number	PMC11007598
Issue Number	3
PubMed reference number	38617844
Journal	Clinics in Colon and Rectal Surgery [Clin Colon Rectal Surg]
e-ISSN	15309681
Language	English
Publisher	Thieme Medical Publishers, Inc.
Publisher Date	2023-08-10
Publisher Place	USA
Access Restriction	Open
Rights License	Thieme. All rights reserved.
Subject Keyword	familial adenomatous polyposis proctocolectomy adenomatous polyposis coli desmoid
Content Type	Text
Resource Type	Article
Subject	Gastroenterology Surgery