Diazines and Triazines as Building Blocks in Ligands for Metal-Mediated Catalytic Transformations.

Content Provider	Europe PMC
Author	Doll, JuliannaS. Becker, Felix J. Roşca, Dragoş-Adrian
Copyright Year	2023
Description	Pyridine is a ubiquitous building block for the design of very diverse ligand platforms, many of which have become indispensable for catalytic transformations. Nevertheless, the isosteric pyrazine, pyrimidine, and triazine congeners have enjoyed thus far a less privileged role in ligand design. In this review, several applications of such fragments in the design of new catalysts are presented. In a significant number of cases described, diazine- and triazine-based ligands either outperform their pyridine congeners or offer alternative catalytic pathways which enable new reactivities. The potential opportunities unlocked by using these building blocks in ligand design are discussed, and the origin of the enhanced catalytic activity is highlighted where mechanistic studies are available.
Abstract	Pyridine is a ubiquitous building block for the designof verydiverse ligand platforms, many of which have become indispensablefor catalytic transformations. Nevertheless, the isosteric pyrazine,pyrimidine, and triazine congeners have enjoyed thus far a less privilegedrole in ligand design. In this review, several applications of suchfragments in the design of new catalysts are presented. In a significantnumber of cases described, diazine- and triazine-based ligands eitheroutperform their pyridine congeners or offer alternative catalyticpathways which enable new reactivities. The potential opportunitiesunlocked by using these building blocks in ligand design are discussed,and the origin of the enhanced catalytic activity is highlighted wheremechanistic studies are available.
Related Links	https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC10853918&blobtype=pdf
Volume Number	4
DOI	10.1021/acsorginorgau.3c00048
PubMed Central reference number	PMC10853918
Issue Number	1
PubMed reference number	38344013
Journal	ACS Organic & Inorganic Au [ACS Org Inorg Au]
e-ISSN	2694247X
Language	English
Publisher	American Chemical Society
Publisher Date	2023-10-23
Access Restriction	Open
Rights License	Permits the broadest form of re-use including for commercial purposes, provided that author attribution and integrity are maintained (https://creativecommons.org/licenses/by/4.0/). © 2023 The Authors. Published by American Chemical Society
Subject Keyword	Ligand design pyrazine pyrimidine triazine metal−ligand cooperativity redox-active ligands mechanistic studies catalysis
Content Type	Text
Resource Type	Article
Subject	Physical and Theoretical Chemistry Inorganic Chemistry Organic Chemistry