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Use of Angiotensin-Converting Enzyme Inhibitors, Angiotensin Receptor Blockers, and Risk of Dementia in Heart Failure.
| Content Provider | Europe PMC |
|---|---|
| Author | Chitnis, Abhishek S. Aparasu, Rajender R. Chen, Hua Kunik, Mark E. Schulz, Paul E. Johnson, Michael L. |
| Copyright Year | 2015 |
| Abstract | Objective:To test the effect of angiotensin-converting enzyme inhibitors (ACEIs) or angiotensin-receptor blockers (ARBs) on reducing the risk of dementia in patients with heart failure (HF).Methods:This retrospective, longitudinal study used a cohort of HF patients identified from a local Medicare advantage prescription drug plan. Multivariable time-dependent Cox model and marginal structural model using inverse-probability-oftreatment weighting were used to estimate the risk of developing dementia. Adjusted dementia rate ratios were estimated among current and former ACEI/ARB users, as compared with nonusers.Results:Using the time-dependent Cox model, the adjusted dementia rate ratios (95% confidence-interval) among current and former users were 0.90(0.70-1.16) and 0.89 (0.71-1.10), respectively. Use of marginal structural model resulted in similar effect estimates for current and former users as compared with the nonusers.Conclusion:This study found no difference in risk of dementia among the current and former users of ACEI/ARB as compared with the nonusers in an already at-risk HF population. |
| Related Links | https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC10852826&blobtype=pdf |
| ISSN | 15333175 |
| Volume Number | 31 |
| DOI | 10.1177/1533317515618799 |
| PubMed Central reference number | PMC10852826 |
| Issue Number | 5 |
| PubMed reference number | 26705381 |
| Journal | American Journal of Alzheimer's Disease and Other Dementias [Am J Alzheimers Dis Other Demen] |
| e-ISSN | 19382731 |
| Language | English |
| Publisher | SAGE Publications |
| Publisher Date | 2015-12-24 |
| Publisher Place | Sage CA: Los Angeles, CA |
| Access Restriction | Open |
| Rights License | © The Author(s) 2015 |
| Subject Keyword | dementia heart failure angiotensin-converting enzyme inhibitors angiotensin receptor blockers |
| Content Type | Text |
| Resource Type | Article |
| Subject | Neuroscience Clinical Psychology Psychiatry and Mental Health Geriatrics and Gerontology |
