Mid-Trimester Spot Urinary Albumin/Creatinine Ratio as a Screening Tool in Prediction of Pre-eclampsia.

Content Provider	Europe PMC
Author	Latha, Akkenapally Prasanna Haripriya, V. Ramya Raj, P.
Abstract	Aims and ObjectivesTo determine utilization of spot urinary albumin/creatinine ratio (UACR) to predict subsequent development of preeclampsia, measured between 17 and 24 weeks of gestational age in asymptomatic antenatal woman and determine their maternal and neonatal outcomes.IntroductionIn preeclampsia the basic pathology is generalized endothelial dysfunction. It causes glomerular endotheliosis which leads to proteinuria, decreased glomerular filtration rate and renal blood flow. Thus microalbuminuria is an early marker which can measured to predict preeclampsia.Materials and MethodsIt is a prospective observational study, carried out for one year in a cohort of asymptomatic antenatal women at 17–24 weeks of gestational age, attending hospital for routine antenatal check-up with a singleton pregnancy and no associated complications. Urine albumin and creatinine ratio (UACR) is measured at first visit, and women were followed till delivery and the maternal and foetal outcomes were recorded.ResultsOut of 81 pregnant women enrolled in the study, 58% belonged to 18–25 years, 54.3% belonged to lower middle class. There was a significant difference in mean UACR among women who developed preeclampsia (PE) and gestational diabetes mellitus (GDM) with p value < 0.05. In the study there was significant association between severe PE, PE and GDM with UACR at 22 as cut-off, with p value < 0.05. In the study among those with UACR > 22, 2.5% had IUFD, 12.5% had LBW, and 7.5% were admitted to NICU.ConclusionWith the measurement of spot UACR in mid-trimester we can predict the development of preeclampsia before the onset of clinical manifestations. UACR > = 171 mg/g predicted preeclampsia well before the onset of clinical manifestations with high sensitivity of 83.3% and specificity of 98.6%.Supplementary InformationThe online version contains supplementary material available at 10.1007/s13224-023-01862-9.
Related Links	https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC10746639&blobtype=pdf
ISSN	09719202
Volume Number	73
DOI	10.1007/s13224-023-01862-9
PubMed Central reference number	PMC10746639
Issue Number	Suppl 2
Issue Number	suppl 2
PubMed reference number	38143992
Journal	Journal of Obstetrics and Gynaecology of India [J Obstet Gynaecol India]
e-ISSN	09756434
Language	English
Publisher	Springer India
Publisher Date	2023-10-31
Publisher Place	New Delhi
Access Restriction	Open
Rights License	© Federation of Obstetric & Gynecological Societies of India 2023. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.
Subject Keyword	Preeclampsia Spot urine albumin/creatinine ratio Antenatal women Proteinuria Gestational hypertension
Content Type	Text
Resource Type	Article
Subject	Obstetrics and Gynecology