NDLI: Recent advances and current challenges in allogeneic stem cell transplantation in patients with acquired severe aplastic anemia

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Recent advances and current challenges in allogeneic stem cell transplantation in patients with acquired severe aplastic anemia

Content Provider	Europe PMC
Author	Lee, Sung-Eun Lee, Jong Wook
Abstract	Allogeneic stem cell transplantation (SCT) from a human leukocyte antigen (HLA)-matched sibling donor (MSD-SCT) is the preferred first-line treatment option for young patients with severe aplastic anemia (SAA). However, only 25% of patients may find an HLA-MSD. SAA patients, who lack a suitable MSD and fail first-line immunosuppressive therapy, may consider SCT from an unrelated donor (URD-SCT) as a treatment option. The results of haplo-identical stem cell transplantation from a related mismatched donor (Haplo-SCT) have improved due to recent advances in controlling graft failure and graft-versus-host disease (GVHD). The use of Haplo-SCT has recently been extended to SAA patients. However, it is important for physicians to select the appropriate conditioning regimen and GVHD prophylaxis to ensure engraftment with reduced toxicity, such as infectious complications and GVHD. This review summarizes recent advances in allogeneic SCT for patients with acquired SAA. Current challenges, including the age of the patients and the effects of donor age, stem cell source, and iron overload on transplantation outcomes are also discussed.
Related Links	https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC10651331&blobtype=pdf
Volume Number	1
DOI	10.31547/bct-2018-001
PubMed Central reference number	PMC10651331
Issue Number	1
PubMed reference number	PMC10651331
Journal	Blood Cell Therapy [Blood Cell Ther]
e-ISSN	24327026
Language	English
Publisher	Asia-Pacific Blood and Marrow Transplantation Group
Publisher Date	2018-08-29
Access Restriction	Open
Rights License	This is an open access article distributed under CC BY-NC license (https://creativecommons.org/licenses/by-nc/4.0/). Copyright Ⓒ2018 Asia-Pacific Blood and Marrow Transplantation Group (APBMT).
Subject Keyword	severe aplastic anemia hematopoietic stem cell transplantation age conditioning regimen iron overload
Content Type	Text
Resource Type	Article
Subject	Biochemistry (medical)

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