NDLI: Successful allogeneic peripheral blood stem cell transplantation for an aggressive variant of T-cell large granular-lymphocyte leukemia: A case report.

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Successful allogeneic peripheral blood stem cell transplantation for an aggressive variant of T-cell large granular-lymphocyte leukemia: A case report.

Content Provider	Europe PMC
Author	Suzuki, Kazuhito Nishiwaki, Kaichi Minami, Jiro Masuoka, Hidekazu Katori, Mitsuji Yokoyama, Hiroki Uryu, Hideki Yano, Shingo
Abstract	The aggressive variant of large granular lymphocyte (LGL) leukemia is very rare and the prognosis of this disease is poor. A 47-year-old woman with progressive pancytopenia and severe liver damage visited our institute. Upon hospitalization, about 30% LGL was detected in her peripheral blood and bone marrow samples. Flow cytometry was conducted to analyze lymphocytes in the bone marrow, which revealed the presence of CD3 and T-cell receptor (TCR) α/β and absence of CD4, CD8, CD16, CD56, CD22, CD79a, and terminal deoxynucleotidyl transferase (TdT). Southern blotting was performed, which revealed the presence of rearrangement of TCR-Cβ1 and Jγ. We made a diagnosis of the aggressive variant of T-LGL leukemia, and performed myeloablative allogeneic peripheral stem cell transplantation (allo-HSCT) from an HLA-matched sibling for primary refractory disease of CHOP and hyper CVAD therapy. She is alive in remission with donor-derived T-LGL lymphocytosis in peripheral blood for 7 years after allo-HSCT. Overall, Allo-HSCT could be active against the aggressive variant of LGL leukemia and induce graft-versus-leukemia effect.
Related Links	https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC10645481&blobtype=pdf
Volume Number	2
DOI	10.31547/bct-2018-006
PubMed Central reference number	PMC10645481
Issue Number	1
PubMed reference number	37969695
Journal	Blood Cell Therapy [Blood Cell Ther]
e-ISSN	24327026
Language	English
Publisher	Asia-Pacific Blood and Marrow Transplantation Group
Publisher Date	2018-10-26
Access Restriction	Open
Rights License	This is an open access article distributed under CC BY-NC license (https://creativecommons.org/licenses/by-nc/4.0/). Copyright Ⓒ2018 Asia-Pacific Blood and Marrow Transplantation Group (APBMT).
Subject Keyword	large granular-lymphocyte leukemia allogeneic hematopoietic stem cell transplantation graft-versus-lymphoma effect
Content Type	Text
Resource Type	Article
Subject	Biochemistry (medical)

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