Anti-obesity effects of Camellia (Camellia oleifera Abel) oil treatment on high-fat diet-induced obesity in C57BL/6J mice.

Content Provider	Europe PMC
Author	Chilakala, Ramakrishna Moon, Hyeon Jeong Kim, Kiwoong Yang, Soyoung Cheong, Sun Hee
Copyright Year	2023
Abstract	[Purpose] In the current study, we investigated the effects of camellia oil and camellia oil infused with herbs (Camellia oleifera Abel) on obesity in obese mice fed a high-fat diet (HFD). [Methods] The antioxidant activity of camellia oil in scavenging free radicals was investigated. Additionally, body and organ weight changes, serum and liver marker parameters, antioxidant enzyme activities, liver and epididymal fat histology, protein and gene expression associated with lipogenesis and hyperglycemia effect on adenosine monophosphate-activated protein kinase (AMPK) phosphorylation, were examined in HFD-induced obese mice. [Results] The hepatic steatosis and epididymal fat were significantly reduced by the oral administration of camellia oil and herb-infused camellia oil. Moreover, hepatic and serum marker parameters such as total cholesterol, insulin, triglycerides, tumor necrosis factor-α, adiponectin, thiobarbituric acid reactive substances, aspartate aminotransferase, and alanine transaminase were beneficially impacted. Additionally, the activity of antioxidant enzymes also increased. Camellia oil and herb-infused camellia oil treatments reduced the expression of genes linked to hyperglycemia and lipogenesis via activation of AMPK phosphorylation. [Conclusion] For many people, exercise poses an obstacle in the daily routine due to lack of ease, difficulty in maintaining consistency, and hard work. Camellia oil combined with herbs has anti-obesity and antihyperglycemic effects. These findings indicate that treatment with herb-infused camellia oil is most beneficial for elderly individuals who do not prefer frequent exercise.
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Volume Number	27
DOI	10.20463/pan.2023.0018
PubMed Central reference number	PMC10440180
Issue Number	2
PubMed reference number	37583072
Journal	Physical Activity and Nutrition [Phys Act Nutr]
e-ISSN	27337545
Language	English
Publisher	Korean Society for Exercise Nutrition
Publisher Date	2023-06-30
Access Restriction	Open
Rights License	This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/2.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. Copyright © 2023 Korean Society for Exercise Nutrition
Subject Keyword	camellia oil herb-infused camellia oil anti-obesity antioxidant activity high-fat diet mouse fat metabolism
Content Type	Text
Resource Type	Article
Subject	Physical Therapy, Sports Therapy and Rehabilitation Physiology Health (social science) Orthopedics and Sports Medicine Nutrition and Dietetics