NDLI: An introduction to RNA-mediated gene silencing.

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An introduction to RNA-mediated gene silencing.

Content Provider	Europe PMC
Author	Geanacopoulos, Mark
Copyright Year	2005
Abstract	Careful analysis of cases where introduction of additional copies of endogenous genes caused coordinate silencing of both the transgene and the endogenous gene laid the ground work for the discovery of RNA-mediated silencing. Silencing begins with the expression and recognition of double-stranded RNA, which is cleaved into short RNAs that recognize, by complementarity, sequences that are targets for down regulation. An RNA target can be regarded (post-transcriptional gene silencing), but the small RNAs can also direct the sequence-specific modification of DNA and chromatin. RNA-mediated gene silencing in eukaryotes may have originated as surveillance mechanism to protect the organism from transposable elements and viruses and then evolved to specify chromosomal modifications and to regulate expression of a significant fraction of endogenous genes by microRNAs. This review seeks to furnish the student and non-expert with some idea of how RNA-mediated silencing was discovered and a broad overview of the present state of knowledge.
Related Links	https://europepmc.org/backend/ptpmcrender.fcgi?accid=PMC10361166&blobtype=pdf
ISSN	00368504
Volume Number	88
DOI	10.3184/003685005783238444
PubMed Central reference number	PMC10361166
Issue Number	1
Issue Number	pt 1
PubMed reference number	16372594
Journal	Science Progress [Sci Prog]
e-ISSN	20477163
Language	English
Publisher	SAGE Publications
Publisher Date	2005-01-01
Publisher Place	Sage UK: London, England
Access Restriction	Open
Rights License	© 2005 SAGE Publications
Subject Keyword	gene silencing RNA interference dicer RISC RNA-mediated gene silencing microRNAs co-supression
Content Type	Text
Resource Type	Article
Subject	Multidisciplinary

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