16S rRNA gene sequencing reveals the correlation between the gut microbiota and the susceptibility to pathological scars.

Content Provider	Europe PMC
Author	Li, Ming Li, Minghao Dai, Yingting Li, Dang Yu, Han Liu, Jian Gao, Hangqi Zhong, Yi Huang, Mingquan Lin, Jing Xie, Yide Guo, Zhihui Chen, Xiaosong
Copyright Year	2023
Abstract	The gut microbiome profile in patients with pathological scars remains rarely known, especially those patients who are susceptible to pathological scars. Previous studies demonstrated that gut microbial dysbiosis can promote the development of a series of diseases via the interaction between gut microbiota and host. The current study aimed to explore the gut microbiota of patients who are prone to suffer from pathological scars. 35 patients with pathological scars (PS group) and 40 patients with normal scars (NS group) were recruited for collection of fecal samples to sequence the 16S ribosomal RNA (16S rRNA) V3-V4 region of gut microbiota. Alpha diversity of gut microbiota showed a significant difference between NS group and PS group, and beta diversity indicated that the composition of gut microbiota in NS and PS participants was different, which implied that dysbiosis exhibits in patients who are susceptible to pathological scars. Based on phylum, genus, species levels, we demonstrated that the changing in some gut microbiota (Firmicutes; Bacteroides; Escherichia coli, etc.) may contribute to the occurrence or development of pathological scars. Moreover, the interaction network of gut microbiota in NS and PS group clearly revealed the different interaction model of each group. Our study has preliminary confirmed that dysbiosis exhibits in patients who are susceptible to pathological scars, and provide a new insight regarding the role of the gut microbiome in PS development and progression.
Page Count	10
ISSN	1664302X
Journal	Frontiers in Microbiology
Volume Number	14
PubMed Central reference number	PMC10332274
PubMed reference number	37434704
e-ISSN	1664302X
DOI	10.3389/fmicb.2023.1215884
Language	English
Publisher	Frontiers Media S.A.
Publisher Date	2023-06-20
Access Restriction	Open
Rights License	This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. Copyright © 2023 Li, Li, Dai, Li, Yu, Liu, Gao, Zhong, Huang, Lin, Xie, Guo and Chen.
Subject Keyword	pathological scars susceptibility gut microbiota 16S rRNA sequencing dysbiosis
Content Type	Text
Resource Type	Article
Subject	Microbiology Microbiology (medical)