The Synaptic and Circuit Functions of Vitamin D in Neurodevelopment Disorders.

Content Provider	Europe PMC
Author	Ye, Xiaoshan Zhou, Qionglin Ren, Pengcheng Xiang, Wei Xiao, Le
Copyright Year	2023
Abstract	AbstractVitamin D deficiency/insufficiency is a public health issue around the world. According to epidemiological studies, low vitamin D levels have been associated with an increased risk of some neurodevelopmental disorders, including autism spectrum disorder (ASD) and attention-deficit hyperactivity disorder (ADHD). Animal models reveal that vitamin D has a variety of impacts on the synapses and circuits in the brain. A lack of vitamin D affects the expression of synaptic proteins, as well as the synthesis and metabolism of various neurotransmitters. Depending on where vitamin D receptors (VDRs) are expressed, vitamin D may also regulate certain neuronal circuits through the endocannabinoid signaling, mTOR pathway and oxytocin signaling. While inconsistently, some data suggest that vitamin D supplementation may be able to reduce the core symptoms of ASD and ADHD. This review emphasizes vitamin D’s role in the synaptic and circuit mechanisms of neurodevelopmental disorders including ASD and ADHD. Future application of vitamin D in these disorders will depend on both basic research and clinical studies, in order to make the transition from the bench to the bedside.
Page Count	16
ISSN	11766328
Volume Number	19
PubMed Central reference number	PMC10327924
PubMed reference number	37424961
Journal	Neuropsychiatric Disease and Treatment [Neuropsychiatr Dis Treat]
e-ISSN	11782021
DOI	10.2147/NDT.S407731
Language	English
Publisher	Dove
Publisher Date	2023-07-03
Access Restriction	Open
Rights License	This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms (https://www.dovepress.com/terms.php). © 2023 Ye et al.
Subject Keyword	vitamin D neurodevelopmental disorders autism spectrum disorder ASD attention-deficit hyperactivity disorder ADHD synapses circuits
Content Type	Text
Resource Type	Article
Subject	Biological Psychiatry Psychiatry and Mental Health